SERPINB3

Gene Symbol SERPINB3
Entrez Gene 6317
Alt Symbol HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade B (ovalbumin), member 3
Other Description protein T4-A|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3|serpin B3|squamous cell carcinoma antigen 1
Swissprots Q9BYF8 Q86W04 Q8IWL4 B3W5Y6 A6NDM2 Q8IXI3 Q86VF3 P29508 Q53H28 B2RBT5 Q96J21 Q53YB5
Accessions AAA86316 AAA86317 BAB21524 EAW63156 EAW63157 P29508 AB046399 BAB40772 AF428135 AAQ04218 AF428136 AAQ04219 AF428137 AAQ04220 AF428138 AAQ04221 AF428139 AAQ04222 AF461146 AAQ04770 AJ515706 CAD56658 AK222746 BAD96466 AK222753 BAD96473 AK307261 AK308383 AK310948 AK314805 BAG37332 AY190327 AAO11731 AY245778 AAO92269 AY245781 AAO92272 BC005224 AAH05224 BC008483 BT006748 AAP35394 DB229922 DQ890560 ABM92177 DQ893722 ABM84648 EU852041 ACF21012 S66896 AAB20405 U19556 AAA97552 NM_006919 NP_008850
Function May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269|PubMed:19166818}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10956412, ECO:0000269|PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
Tissue Specificity Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). {ECO:0000269|PubMed:14970861}.
Top Pathways Amoebiasis

SCCA1 (8H11) - sc-21767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SCCA1 (8H11): sc-21767. Immunoperoxidase staining of paraffin-embedded human psoratic skin tissue. Kindly provided by Dr. Gary Silverman of Childrens Hospital, Boston.

SCCA1/2 (C-18) - sc-21891 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SCCA1/2 (H-390) - sc-25499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SCCA1/2 (H-390): sc-25499. Western blot analysis of SCCA1 expression in non-transfected: sc-117752 (A) and human SCCA1 transfected: sc-158948 (B) 293T whole cell lysates.

SCCA1/2 (T-17) - sc-21893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SERPINB3/4 antibody - ab190756 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SERPINB3/4 antibody (ab190756) at 1/500 dilution + Jurkat cell lysate

Anti-SerpinB3 antibody - ab55733 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing A431 cells stained with ab55733 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab55733, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-SerpinB3 antibody - ab154971 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SerpinB3 antibody (ab154971) at 1/3000 dilution + HCT116 whole cell lysate at 30 µg

Anti-SerpinB3 antibody - ab201081 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SerpinB3 antibody (ab201081)Lane 1 : THP-1 whole cell lysateLane 2 : PC12 whole cell lysateLane 3 : sp20 whole cell lysate

Anti-SerpinB3 antibody - ab47726 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SerpinB3 antibody (ab47726) at 1/1000 dilutionLane 1 : HFL-1 Cell lysateLane 2 : HFL-1 Cell lysateLane 3 : HFL-1 Cell lysateLysates/proteins at 20 µl per lane.

Anti-SerpinB3 antibody - ab186842 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SerpinB3 antibody (ab186842) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : M21 cell extractLane 3 : H375 cell extractLane 4 : HepG2 cell extractLane 5 : 293T cell extractLane 6 : SHSY-5Y cell extractLane 7 : OVCAR3 cell extract

Anti-SerpinB3 antibody [1A5] - ab180396 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A5
All lanes : Anti-SerpinB3 antibody [1A5] (ab180396) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB3 cDNALysates/proteins at 5 µg per lane.

Anti-SerpinB3 antibody [3C2] - ab118143 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2
All lanes : Anti-SerpinB3 antibody [3C2] (ab118143) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB3 cDNALysates/proteins at 5 µg per lane.

Anti-SERPINB3 Antibody - LS-C318420 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human liver cancer using SERPINB3 / SCC antibody at dilution 1:100.

Anti-SERPINB3 Antibody (clone 1C12) - LS-C338249 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C12
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB3.

Anti-SERPINB3 Antibody (clone 3C2) - LS-C172560 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2
IHC of paraffin-embedded Human pancreas tissue using anti-SERPINB3 mouse monoclonal antibody.

Anti-SERPINB3 Antibody - LS-C335566 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SERPINB3 antibody.

Anti-SerpinB3 Antibody (C-Terminus, clone EPR5157) IHC-plus™ - LS-B9382 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5157
Anti-SERPINB3 / SCCA-1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SERPINB3 Antibody (clone 1A10) - LS-C338250 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB3.

Anti-SERPINB3 Antibody (clone 3E8) - LS-C338318 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB3.

Anti-SERPINB3 Antibody - LS-C341615 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINB3 Antibody (clone 2B9) - LS-C338314 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB3.

Anti-SERPINB3 Antibody (clone 2H2) - LS-C338302 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB3.

Anti-SERPINB3 Antibody (clone 2H4) - LS-C338316 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB3.

Anti-SERPINB3 Antibody (clone 1C10) - LS-C338240 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C10
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-SERPINB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-SERPINB3 Antibody (clone 3G4) - LS-C338338 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G4
Immunofluorescent staining of HeLa cells using anti-SERPINB3 mouse monoclonal antibody.
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