SERPINB3

Gene Symbol	SERPINB3
Entrez Gene	6317
Alt Symbol	HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade B (ovalbumin), member 3
Other Description	protein T4-A|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3|serpin B3|squamous cell carcinoma antigen 1
Swissprots	Q9BYF8 Q86W04 Q8IWL4 B3W5Y6 A6NDM2 Q8IXI3 Q86VF3 P29508 Q53H28 B2RBT5 Q96J21 Q53YB5
Accessions	AAA86316 AAA86317 BAB21524 EAW63156 EAW63157 P29508 AB046399 BAB40772 AF428135 AAQ04218 AF428136 AAQ04219 AF428137 AAQ04220 AF428138 AAQ04221 AF428139 AAQ04222 AF461146 AAQ04770 AJ515706 CAD56658 AK222746 BAD96466 AK222753 BAD96473 AK307261 AK308383 AK310948 AK314805 BAG37332 AY190327 AAO11731 AY245778 AAO92269 AY245781 AAO92272 BC005224 AAH05224 BC008483 BT006748 AAP35394 DB229922 DQ890560 ABM92177 DQ893722 ABM84648 EU852041 ACF21012 S66896 AAB20405 U19556 AAA97552 NM_006919 NP_008850
Function	May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269|PubMed:19166818}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10956412, ECO:0000269|PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
Tissue Specificity	Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). {ECO:0000269|PubMed:14970861}.
Top Pathways	Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SerpinB3 full length protein - ab114533 from Abcam Category Protein Source Wheat germ Species Human

Human SerpinB3 full length protein - ab202159 from Abcam Category Protein Source E. coli Species Human

Human SerpinB3 protein fragment - ab114532 from Abcam Category Protein Source Wheat germ Species Human

SERPINB3 Antibody Blocking Peptide - LS-E8303 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Serpin B3/SCCA1 Protein - H00006317-Q01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human Serpin B3/SCCA1 Protein - H00006317-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

SPB3-Antibody-N-term-Blocking-Peptide - BP6579a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Serpin B3/SSCA1, CF - 6528-PI-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Asn2-Pro390, with an N-terminal Met and 6-His tag

Recombinant human Serpin B3 (OPCA00906) - OPCA00906 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human SERPINB3 protein (His Tag) - orb139646 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

Human SERPINB3 protein - orb245494 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SERPINB3 protein - 80R-4230 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

SERPINB3 / SCCA1 (1-390, His-tag) - AR51912PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SERPINB3 / SCCA1 (1-390, His-tag) - AR51912PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SERPINB3 / SCCA1 - H00006317-P01-10 from Acris Antibodies Category Protein Species Human

SERPINB3 / SCCA1 - H00006317-P01-25 from Acris Antibodies Category Protein Species Human

SERPINB3 / SCCA1 - H00006317-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SERPINB3 / SCCA1 - H00006317-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Serpin B3 (SCCA1), HEK293 Lysate - 230-10061-100 from RayBiotech Category Protein Prices $154.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Serpin B3 (SCCA1), HEK293 Transfected Cell Culture Supernatant - 230-20037-200 from RayBiotech Category Protein Prices $113.00 Sizes 200 µl Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Serpin B3 (SCCA1) - 230-30005-10 from RayBiotech Category Protein Prices $149.00 Sizes 10 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Serpin B3 (SCCA1) - 230-30005-50 from RayBiotech Category Protein Prices $299.00 Sizes 50 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Serpin B3 (SCCA1) - 230-30005-100 from RayBiotech Category Protein Prices $499.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Squamous Cell Carcinoma Antigen 1 (SCCA1), Human - 20-7679 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

SERPINB3 fusion protein - Ag8669 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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