Gene Symbol | CABP1 |
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Entrez Gene | 9478 |
Alt Symbol | CALBRAIN, HCALB_BR |
Species | Human |
Gene Type | protein-coding |
Description | calcium binding protein 1 |
Other Description | calcium binding protein 5|calcium-binding protein 1|caldendrin |
Swissprots | O95663 Q9NZU8 Q8N6H5 Q9NZU7 |
Accessions | EAW98209 EAW98210 EAW98211 Q9NZU7 AF169148 AAF25782 AF169149 AAF25783 AK127203 AL533429 BC015006 BC030201 AAH30201 BM716422 BQ188859 DQ895513 ABM86439 EU176343 ABW03794 NM_001033677 NP_001028849 NM_004276 NP_004267 NM_031205 NP_112482 |
Function | Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity). {ECO:0000250}. |
Subcellular Location | Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=S- CaBP1 is localized at or near the plasma membrane. |
Tissue Specificity | Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum. |
CaBP (A-4) - sc-365522 from Santa Cruz Biotechnology
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CaBP (F-5) - sc-514449 from Santa Cruz Biotechnology
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CaBP (H-37) - sc-367381 from Santa Cruz Biotechnology
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CaBP (V-20) - sc-28085 from Santa Cruz Biotechnology
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Anti-CABP antibody - ab128381 from Abcam
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Anti-CABP antibody - ab2936 from Abcam
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Anti-CABP antibody [EPR7916] - ab128910 from Abcam
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Anti-CABP antibody - Azide free - ab37748 from Abcam
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Anti-CABP antibody - Carboxyterminal end - ab75949 from Abcam
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Anti-CABP / CABP1 Antibody (Internal, clone EPR7916) - LS-C152545 from LifeSpan Bioscience
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Anti-CABP / CABP1 Antibody (aa108-157) - LS-C146557 from LifeSpan Bioscience
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Anti-CABP / CABP1 Antibody (aa2-13) - LS-C54488 from LifeSpan Bioscience
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Anti-CABP / CABP1 Antibody (aa311-343) - LS-C100222 from LifeSpan Bioscience
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CABP1 Antibody - NBP1-98550 from Novus Biologicals
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CABP1 Antibody - NB100-1087 from Novus Biologicals
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Anti-CABP1 antibody produced in rabbit - HPA051438 from Sigma-Aldrich
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ANTI-CABP1(C-TERMINAL) antibody produced in rabbit - SAB1307121 from Sigma-Aldrich
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Anti-CABP1 antibody produced in chicken - GW22822 from Sigma-Aldrich
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CABP1 antibody - N-terminal region (ARP63909_P050) - ARP63909_P050 from Aviva Systems Biology
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CABP1-Antibody-C-term - AP7588b from Abgent, a WuXi AppTec company
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CABP1-Antibody - AF1174a from Abgent, a WuXi AppTec company
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CABP1 Antibody - C-terminal region (OAAB04628) - OAAB04628 from Aviva Systems Biology
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CABP antibody - GTX22936 from GeneTex
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CABP1 antibody - GTX82436 from GeneTex
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CABP1 antibody, C-term - GTX81376 from GeneTex
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