| Gene Symbol |
TRIM32
|
| Entrez Gene |
22954
|
| Alt Symbol |
BBS11, HT2A, LGMD2H, TATIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 32
|
| Other Description |
72 kDa Tat-interacting protein|E3 ubiquitin-protein ligase TRIM32|TAT-interactive protein, 72-KD|tripartite motif-containing 32|tripartite motif-containing protein 32|zinc finger protein HT2A|zinc-finger protein HT2A
|
| Swissprots |
Q13049 Q9NQP8
|
| Accessions |
CAX86996 CAY39310 EAW87446 EAW87447 Q13049 AK314264 AX775779 CAE11589 BC003154 AAH03154 BI544919 BX091494 DN991209 DQ893081 ABM84007 DQ896342 ABM87341 U18543 AAA86474 XM_005251813 XP_005251870 XM_011518396 XP_011516698 XM_011518397 XP_011516699 XM_011518398 XP_011516700 NM_001099679 NP_001093149 NM_012210 NP_036342
|
| Function |
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. {ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:22500027}.
|
| Subcellular Location |
Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.
|
| Tissue Specificity |
Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle. {ECO:0000269|PubMed:11822024}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|