Gene Symbol | TRIM32 |
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Entrez Gene | 22954 |
Alt Symbol | BBS11, HT2A, LGMD2H, TATIP |
Species | Human |
Gene Type | protein-coding |
Description | tripartite motif containing 32 |
Other Description | 72 kDa Tat-interacting protein|E3 ubiquitin-protein ligase TRIM32|TAT-interactive protein, 72-KD|tripartite motif-containing 32|tripartite motif-containing protein 32|zinc finger protein HT2A|zinc-finger protein HT2A |
Swissprots | Q13049 Q9NQP8 |
Accessions | CAX86996 CAY39310 EAW87446 EAW87447 Q13049 AK314264 AX775779 CAE11589 BC003154 AAH03154 BI544919 BX091494 DN991209 DQ893081 ABM84007 DQ896342 ABM87341 U18543 AAA86474 XM_005251813 XP_005251870 XM_011518396 XP_011516698 XM_011518397 XP_011516699 XM_011518398 XP_011516700 NM_001099679 NP_001093149 NM_012210 NP_036342 |
Function | Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. {ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:22500027}. |
Subcellular Location | Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus. |
Tissue Specificity | Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle. {ECO:0000269|PubMed:11822024}. |
Top Pathways | Ubiquitin mediated proteolysis |
TRIM32 CRISPR/Cas9 KO Plasmid (h) - sc-402731 from Santa Cruz Biotechnology
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TRIM32 HDR Plasmid (h) - sc-402731-HDR from Santa Cruz Biotechnology
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TRIM32 Double Nickase Plasmid (h) - sc-402731-NIC from Santa Cruz Biotechnology
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TRIM32 Double Nickase Plasmid (h2) - sc-402731-NIC-2 from Santa Cruz Biotechnology
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TRIM32 CRISPR Activation Plasmid (h) - sc-402731-ACT from Santa Cruz Biotechnology
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TRIM32 CRISPR Activation Plasmid (h2) - sc-402731-ACT-2 from Santa Cruz Biotechnology
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TRIM32 Lentiviral Activation Particles (h) - sc-402731-LAC from Santa Cruz Biotechnology
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TRIM32 Lentiviral Activation Particles (h2) - sc-402731-LAC-2 from Santa Cruz Biotechnology
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TRIM32 siRNA (h) - sc-61714 from Santa Cruz Biotechnology
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TRIM32 shRNA Plasmid (h) - sc-61714-SH from Santa Cruz Biotechnology
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TRIM32 shRNA (h) Lentiviral Particles - sc-61714-V from Santa Cruz Biotechnology
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TRIM32 RNAi - H00022954-R01V from Novus Biologicals
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MISSION® esiRNA - EHU029161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21970 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21970 from Sigma-Aldrich
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TRIM32 siRNA (Human) - CRH7897 from Cohesion Biosciences
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TRIM32 RNAi - H00022954-R01 from Novus Biologicals
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TRIM32 - MBS8225444 from MyBioSource
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shRNA set against Human TRIM32 (NM_012210.3) - SHH434612 from Creative biogene
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shRNA set against Human TRIM32(NM_012210.3) - SHL094098 from Creative biogene
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Human TRIM32 siRNA - orb268399 from Biorbyt
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TRIM32 shRNA Plasmid (Human) - CHH7897 from Cohesion Biosciences
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TRIM32 miRNA 3'UTR clone - MiUTR1H-10732 from Creative biogene
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TRIM32 miRNA 3'UTR clone - MiUTR3H-04847 from Creative biogene
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