| Gene Symbol | BIN2 |
|---|---|
| Entrez Gene | 51411 |
| Alt Symbol | BRAP-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | bridging integrator 2 |
| Other Description | breast cancer associated protein BRAP1|breast cancer-associated protein 1|bridging integrator-2 |
| Swissprots | Q9UBW5 Q9UKN4 Q86VV0 Q9NWK4 |
| Accessions | BAA88125 EAW58186 EAW58187 EAW58188 Q9UBW5 AB032698 BAA88108 AF146531 AAD54227 AK000783 BAA91376 AK093638 AK225911 AK300211 BAH13239 AK314304 BAG36957 BC047686 AAH47686 BG388638 BX281612 CB996605 DB035315 XM_005268957 XP_005269014 XM_005268958 XP_005269015 XM_011538452 XP_011536754 XM_011538453 XP_011536755 NM_001290007 NP_001276936 NM_001290008 NP_001276937 NM_001290009 NP_001276938 NM_016293 NP_057377 |
| Function | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Subcellular Location | Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. |
| Tissue Specificity | Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. {ECO:0000269|PubMed:10903846, ECO:0000269|PubMed:23285027}. |