BIN2

Gene Symbol BIN2
Entrez Gene 51411
Alt Symbol BRAP-1
Species Human
Gene Type protein-coding
Description bridging integrator 2
Other Description breast cancer associated protein BRAP1|breast cancer-associated protein 1|bridging integrator-2
Swissprots Q9UBW5 Q9UKN4 Q86VV0 Q9NWK4
Accessions BAA88125 EAW58186 EAW58187 EAW58188 Q9UBW5 AB032698 BAA88108 AF146531 AAD54227 AK000783 BAA91376 AK093638 AK225911 AK300211 BAH13239 AK314304 BAG36957 BC047686 AAH47686 BG388638 BX281612 CB996605 DB035315 XM_005268957 XP_005269014 XM_005268958 XP_005269015 XM_011538452 XP_011536754 XM_011538453 XP_011536755 NM_001290007 NP_001276936 NM_001290008 NP_001276937 NM_001290009 NP_001276938 NM_016293 NP_057377
Function Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Subcellular Location Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.
Tissue Specificity Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. {ECO:0000269|PubMed:10903846, ECO:0000269|PubMed:23285027}.

BIN2 (B-10) - sc-376690 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BIN2 (B-10): sc-376690. Western blot analysis of BIN2 expression in non-transfected: sc-117752 (A) and human BIN2 transfected: sc-116101 (B) 293T whole cell lysates.

BIN2 (E-2) - sc-376391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BIN2 (E-2): sc-376391. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

BIN2 (H-70) - sc-134647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BIN2 (H-70): sc-134647. Western blot analysis of BIN2 expression in mouse spleen (A) and rat spleen (B) tissue extracts.

BIN2 (F-12) - sc-376691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BIN2 (F-12): sc-376691. Western blot analysis of BIN2 expression in non-transfected: sc-117752 (A) and human BIN2 transfected: sc-116101 (B) 293T whole cell lysates.

BIN2 (S-14) - sc-167204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BIN2 (S-14): sc-167204. Western blot analysis of BIN2 expression in non-transfected: sc-117752 (A) and human BIN2 transfected: sc-116101 (B) 293T whole cell lysates.

Anti-BIN2 antibody - ab108226 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BIN2 antibody (ab108226) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-BIN2 antibody - N-terminal - ab175482 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BIN2 antibody - N-terminal (ab175482) at 1/1000 dilutionLane 1 : HL60 cell line lysateLane 2 : CEM cell line lysateLane 3 : MDA-MB435 cell line lysateLane 4 : A549 cell line lysateLysates/proteins at 15 µg per lane.

Anti-BIN2 Antibody (N-Terminus, APC) - LS-C221531 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (N-Terminus, AP) - LS-C221530 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (N-Terminus, Biotin) - LS-C221532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (N-Terminus, FITC) - LS-C221533 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (N-Terminus, Azide-free, HRP) - LS-C221534 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (N-Terminus, PE) - LS-C221536 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (N-Terminus) - LS-C319840 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 Antibody (aa359-408) - LS-C117196 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BIN2 antibody LS-C117196 Western blot of Fetal Heart lysate.

Anti-BIN2 Antibody - LS-C155633 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: HepG2 10% SDS PAGE BIN2 antibody diluted at 1:1000

Anti-BIN2 Antibody (aa14-42) - LS-C156818 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BIN2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

BIN2 Antibody - NBP1-79648 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BIN2 Antibody [NBP1-79648] - Human Heart lysate, concentration 0.2-1 ug/ml.

BIN2 Antibody - NBP2-15588 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BIN2 Antibody [NBP2-15588] - Sample (30 ug of whole cell lysate) A: HepG2 10% SDS PAGE gel, diluted at 1:1000.

BIN2 Polyclonal Antibody - bs-9727R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BIN2 (482-494) antibody produced in rabbit - SAB1101467 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>ANTI-BIN2 (482-494): <B>Cat. No. SAB1101467</B>: Immunofluorescence of HUVEC cells using BIN2 (482-494), Cat. No. SAB1101467 (red) at a 1:100 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

ANTI-BIN2 (N-TERM) antibody produced in rabbit - SAB1303036 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>BIN2 (N-term): <B>Cat. No. SAB1303036</B>: BIN2 in Human colon carcinoma tissue with BIN2 antibody (N-term) at 5 μg/mL.

Anti-BIN2 antibody produced in rabbit - SAB2107224 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-BIN2: <B>Cat. No. SAB2107224</B>: Western blot analysis of BIN2 with BIN2 (bridging integrator 2) antibody against the middle region of BIN2 (50 μg) antibody at 1.0 μg/mL.

Anti-BIN2 antibody produced in rabbit - SAB2700665 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-BIN2: <B>Cat. No. SAB2700665</B>: Western Blot analysis of BIN2 in extracts from <B>Lanes</B><BR/>A. HepG2 using <B>Cat. No. SAB2700665</B> at a 1:1000 dilution.

Anti-BIN2 antibody produced in rabbit - HPA038666 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BIN2: <B>Cat. No. HPA038666</B>: Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells in red pulp.
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