SERPINF1

Gene Symbol SERPINF1
Entrez Gene 5176
Alt Symbol EPC-1, OI12, OI6, PEDF, PIG35
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Other Description cell proliferation-inducing gene 35 protein|pigment epithelium-derived factor|serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1|serpin F1
Swissprots Q96R01 Q96CT1 P36955 Q2TU83 Q13236 Q9BWA4 F1T092
Accessions AAA84914 EAW90577 P36955 AA351026 AA658568 AB593011 BAJ83966 AB593012 BAJ83967 AB593013 BAJ83968 AF400442 AAK92491 AK315344 AY513280 AAT08033 BC000522 AAH00522 BC013984 AAH13984 BM981180 BQ773314 BT007222 AAP35886 BU154385 CA405781 JF432524 ADZ15741 M76979 AAA60058 M90439 AAA93524 W22661 NM_002615 NP_002606
Function Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.
Subcellular Location Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.
Tissue Specificity Retinal pigment epithelial cells and blood plasma. {ECO:0000269|PubMed:12737624}.

PEDF (D-10) - sc-390172 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEDF (D-10): sc-390172. Western blot analysis of PEDF expression in non-transfected 293T: sc-117755 (A), human PEDF transfected 293T: sc-158841 (B) and Y79 (C) whole cell lysates.

PEDF (H-125) - sc-25594 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PEDF (H-125) sc-25594. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

PEDF (I-15) - sc-16956 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PEDF (I-15): sc-16956. Western blot analysis of human recombinant PEDF fusion protein.

PEDF (H-9) - sc-390066 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEDF (H-9): sc-390066. Western blot analysis of PEDF expression in Y79 whole cell lysate.

PEDF (LL-J) - sc-74254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PEDF (LL-J): sc-74254. Western blot analysis of PEDF expression in non-transfected: sc-117752 (A) and human PEDF transfected: sc-158841 (B) 293T whole cell lysates.

Anti-PEDF antibody - ab14993 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PEDF antibody - ab85232 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PEDF antibody (ab85232) at 1/50 dilution + K562 cell line lysate at 35 µg

Anti-PEDF antibody - ab74439 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PEDF antibody (ab74439) at 1 µg/mlLane 1 : Human Plasma Total Protein Lysate Lane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-PEDF antibody [1C4] - ab115489 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
Overlay histogram showing K562 cells stained with ab115489 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab115489, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in K562 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-PEDF antibody [EPR9826(B)] - ab157207 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9826(B)
All lanes : Anti-PEDF antibody [EPR9826(B)] (ab157207) at 1/1000 dilutionLane 1 : Human plasmaLane 2 : Human serumLane 3 : Y79 lysateLane 4 : A549 lysateLane 5 : 293T lysateLane 6 : K562 lysateLysates/proteins at 10 µg per lane.

Anti-SERPINF1 / PEDF Antibody (clone 1C4) IHC-plus™ - LS-B2928 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 1C4
Anti-PEDF antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2928 concentration 10 ug/ml.

Anti-SERPINF1 / PEDF Antibody (aa19-389) - LS-C295917 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa125-261) - LS-C295918 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa262-417) - LS-C295920 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa19-389, Biotin) - LS-C298520 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa125-261, Biotin) - LS-C299183 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa262-417, Biotin) - LS-C300221 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa125-261, FITC) - LS-C302555 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa19-389, FITC) - LS-C302654 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (aa262-417, FITC) - LS-C304144 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody - LS-C340728 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody - LS-C340780 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-SERPINF1 / PEDF Antibody (Thr307) - LS-C177223 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of PEDF (T307) pAb in paraffin-embedded human prostate carcinoma tissue.

Anti-SERPINF1 / PEDF Antibody - LS-C192859 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of human liver cell lines, using SERPINF1 antibody.

Anti-SERPINF1 / PEDF Antibody (Biotin) - LS-C342970 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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