| Gene Symbol |
SERPINF1
|
| Entrez Gene |
5176
|
| Alt Symbol |
EPC-1, OI12, OI6, PEDF, PIG35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
|
| Other Description |
cell proliferation-inducing gene 35 protein|pigment epithelium-derived factor|serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1|serpin F1
|
| Swissprots |
Q96R01 Q96CT1 P36955 Q2TU83 Q13236 Q9BWA4 F1T092
|
| Accessions |
AAA84914 EAW90577 P36955 AA351026 AA658568 AB593011 BAJ83966 AB593012 BAJ83967 AB593013 BAJ83968 AF400442 AAK92491 AK315344 AY513280 AAT08033 BC000522 AAH00522 BC013984 AAH13984 BM981180 BQ773314 BT007222 AAP35886 BU154385 CA405781 JF432524 ADZ15741 M76979 AAA60058 M90439 AAA93524 W22661 NM_002615 NP_002606
|
| Function |
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.
|
| Tissue Specificity |
Retinal pigment epithelial cells and blood plasma. {ECO:0000269|PubMed:12737624}.
|
![Western Blot: PEDF Overexpression Lysate (Adult Normal) [NBL1-15854] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PEDF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9646_PEDF%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15854-img0002.jpg)