Gene Symbol | SERPINF1 |
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Entrez Gene | 5176 |
Alt Symbol | EPC-1, OI12, OI6, PEDF, PIG35 |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
Other Description | cell proliferation-inducing gene 35 protein|pigment epithelium-derived factor|serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1|serpin F1 |
Swissprots | Q96R01 Q96CT1 P36955 Q2TU83 Q13236 Q9BWA4 F1T092 |
Accessions | AAA84914 EAW90577 P36955 AA351026 AA658568 AB593011 BAJ83966 AB593012 BAJ83967 AB593013 BAJ83968 AF400442 AAK92491 AK315344 AY513280 AAT08033 BC000522 AAH00522 BC013984 AAH13984 BM981180 BQ773314 BT007222 AAP35886 BU154385 CA405781 JF432524 ADZ15741 M76979 AAA60058 M90439 AAA93524 W22661 NM_002615 NP_002606 |
Function | Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes. |
Tissue Specificity | Retinal pigment epithelial cells and blood plasma. {ECO:0000269|PubMed:12737624}. |
PEDF CRISPR/Cas9 KO Plasmid (h) - sc-400849 from Santa Cruz Biotechnology
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PEDF HDR Plasmid (h) - sc-400849-HDR from Santa Cruz Biotechnology
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PEDF Double Nickase Plasmid (h) - sc-400849-NIC from Santa Cruz Biotechnology
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PEDF Double Nickase Plasmid (h2) - sc-400849-NIC-2 from Santa Cruz Biotechnology
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PEDF CRISPR Activation Plasmid (h) - sc-400849-ACT from Santa Cruz Biotechnology
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PEDF CRISPR Activation Plasmid (h2) - sc-400849-ACT-2 from Santa Cruz Biotechnology
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PEDF Lentiviral Activation Particles (h) - sc-400849-LAC from Santa Cruz Biotechnology
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PEDF Lentiviral Activation Particles (h2) - sc-400849-LAC-2 from Santa Cruz Biotechnology
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PEDF siRNA (h) - sc-40947 from Santa Cruz Biotechnology
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PEDF shRNA Plasmid (h) - sc-40947-SH from Santa Cruz Biotechnology
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PEDF shRNA (h) Lentiviral Particles - sc-40947-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1129 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1129 from Sigma-Aldrich
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SERPINF1 siRNA (Human) - CRH3455 from Cohesion Biosciences
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SERPINF1 - MBS8240529 from MyBioSource
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shRNA set against Human SERPINF1 (NM_002615.5) - SHH405384 from Creative biogene
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SERPINF1 shRNA Plasmid (Human) - CHH3455 from Cohesion Biosciences
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SERPINF1 miRNA 3'UTR clone - MiUTR3H-01753 from Creative biogene
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