| Gene Symbol |
E2F8
|
| Entrez Gene |
79733
|
| Alt Symbol |
E2F-8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 8
|
| Other Description |
E2F family member 8|transcription factor E2F8
|
| Swissprots |
Q9H5M0 Q3C1U6 Q5BKY4 Q2VPJ3 A8K9H3 A0AVK6 Q8N340
|
| Accessions |
A0AVK6 EAW68354 AB231781 BAE46901 AB231782 AB231783 AK026964 BAB15605 AK055206 AK225338 AK292688 BAF85377 BC028244 AAH28244 BC090877 AAH90877 BC108700 AAI08701 BC126400 AAI26401 BC126402 AAI26403 BM972658 BU164108 BX504614 CB959621 DA758300 HQ258679 ADR83430 XM_011520367 XP_011518669 XM_011520368 XP_011518670 XR_930907 NM_001256371 NP_001243300 NM_001256372 NP_001243301 NM_024680 NP_078956
|
| Function |
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15897886}.
|