E2F8
| Gene Symbol | E2F8 |
|---|---|
| Entrez Gene | 79733 |
| Alt Symbol | E2F-8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 8 |
| Other Description | E2F family member 8|transcription factor E2F8 |
| Swissprots | Q9H5M0 Q3C1U6 Q5BKY4 Q2VPJ3 A8K9H3 A0AVK6 Q8N340 |
| Accessions | A0AVK6 EAW68354 AB231781 BAE46901 AB231782 AB231783 AK026964 BAB15605 AK055206 AK225338 AK292688 BAF85377 BC028244 AAH28244 BC090877 AAH90877 BC108700 AAI08701 BC126400 AAI26401 BC126402 AAI26403 BM972658 BU164108 BX504614 CB959621 DA758300 HQ258679 ADR83430 XM_011520367 XP_011518669 XM_011520368 XP_011518670 XR_930907 NM_001256371 NP_001243300 NM_001256372 NP_001243301 NM_024680 NP_078956 |
| Function | Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15897886}. |
E2F-8 CRISPR/Cas9 KO Plasmid (h) - sc-406972 from Santa Cruz Biotechnology
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E2F-8 HDR Plasmid (h) - sc-406972-HDR from Santa Cruz Biotechnology
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E2F-8 Double Nickase Plasmid (h) - sc-406972-NIC from Santa Cruz Biotechnology
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E2F-8 Double Nickase Plasmid (h2) - sc-406972-NIC-2 from Santa Cruz Biotechnology
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E2F-8 CRISPR Activation Plasmid (h) - sc-406972-ACT from Santa Cruz Biotechnology
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E2F-8 CRISPR Activation Plasmid (h2) - sc-406972-ACT-2 from Santa Cruz Biotechnology
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E2F-8 Lentiviral Activation Particles (h) - sc-406972-LAC from Santa Cruz Biotechnology
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E2F-8 Lentiviral Activation Particles (h2) - sc-406972-LAC-2 from Santa Cruz Biotechnology
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E2F-8 siRNA (h) - sc-96849 from Santa Cruz Biotechnology
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E2F-8 shRNA Plasmid (h) - sc-96849-SH from Santa Cruz Biotechnology
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E2F-8 shRNA (h) Lentiviral Particles - sc-96849-V from Santa Cruz Biotechnology
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E2F8 RNAi - H00079733-R01 from Novus Biologicals
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MISSION® esiRNA - EHU025641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7610 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7610 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04354 from Sigma-Aldrich
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E2F8 siRNA (Human) - CRJ2523 from Cohesion Biosciences
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E2F8 - MBS8234663 from MyBioSource
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E2F-8 CRISPR/Cas9 KO Plasmid (h2) - sc-406972-KO-2 from Santa Cruz Biotechnology
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E2F-8 HDR Plasmid (h2) - sc-406972-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human E2F8 (NM_024680.3) - SHH282565 from Creative biogene
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Human E2F8 siRNA - orb273024 from Biorbyt
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E2F8 shRNA Plasmid (Human) - CHJ2523 from Cohesion Biosciences
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E2F8 miRNA 3'UTR clone - MiUTR4H-TG02935 from Creative biogene
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