E2F8

Gene Symbol	E2F8
Entrez Gene	79733
Alt Symbol	E2F-8
Species	Human
Gene Type	protein-coding
Description	E2F transcription factor 8
Other Description	E2F family member 8|transcription factor E2F8
Swissprots	Q9H5M0 Q3C1U6 Q5BKY4 Q2VPJ3 A8K9H3 A0AVK6 Q8N340
Accessions	A0AVK6 EAW68354 AB231781 BAE46901 AB231782 AB231783 AK026964 BAB15605 AK055206 AK225338 AK292688 BAF85377 BC028244 AAH28244 BC090877 AAH90877 BC108700 AAI08701 BC126400 AAI26401 BC126402 AAI26403 BM972658 BU164108 BX504614 CB959621 DA758300 HQ258679 ADR83430 XM_011520367 XP_011518669 XM_011520368 XP_011518670 XR_930907 NM_001256371 NP_001243300 NM_001256372 NP_001243301 NM_024680 NP_078956
Function	Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different
Subcellular Location	Nucleus {ECO:0000269|PubMed:15897886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E2F8 full length protein - ab153513 from Abcam Category Protein Source Wheat germ Species Human

E2F8 Antibody Blocking Peptide - LS-E17296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E2F8 Antibody Blocking Peptide - LS-E26940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human E2F8 Protein - H00079733-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

E2F8 blocking peptide - GTX88498-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

E2F8 Immunizing peptide - orb55052 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

E2F8 Blocking Peptide - 33R-7652 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

E2F8 Peptide - AC21-1769-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

E2F8 - H00079733-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

E2F8 - H00079733-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

E2F8 Peptide - 42-060P from ProSci Category Peptide

E2F8 fusion protein - ag4216 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Transcription factor E2F8(E2F8) ,partial - CSB-YP007349HU CSB-EP007349HU CSB-BP007349HU CSB-MP007349HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

E2F8, Peptide - MBS425226 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

E2F8-Blocking-Peptide-C-Term - BP21882b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E2F8 Peptide, Human - M34GP04671H from Creative Peptides Category Peptide Source Synthetic. Species Human

E2F8 Recombinant Protein Antigen - NBP2-57373PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human E2F8 Protein, GST-tagged - E2F8-4284H from Creative Biomart Category Protein Source Wheat Germ Species Human

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