| Gene Symbol |
INSRR
|
| Entrez Gene |
3645
|
| Alt Symbol |
IRR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin receptor-related receptor
|
| Other Description |
IR-related receptor|insulin receptor-related protein
|
| Swissprots |
P14616 Q5VZS3 O60724
|
| Accessions |
EAW52903 EAW52904 P14616 AF064078 AAC17167 AK310760 BC156081 AAI56082 BC157044 AAI57045 J05046 AAC31759 JQ991924 AFM93766 NM_014215 NP_055030
|
| Function |
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269|PubMed:21641549}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Prostate cancer, Regulation of actin cytoskeleton
|
![Western Blot: IR-related receptor Overexpression Lysate (Adult Normal) [NBP2-10334] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IR-related receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10269_IR-related%2520receptor%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10334-img0001.jpg)