| Gene Symbol |
SPATA18
|
| Entrez Gene |
132671
|
| Alt Symbol |
Mieap, SPETEX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spermatogenesis associated 18
|
| Other Description |
mitochondria-eating protein|spermatogenesis associated 18 homolog|spermatogenesis-associated protein 18
|
| Swissprots |
Q8N7D7 B4E2R0 Q8IY48 Q8TC71 E5RLK1
|
| Accessions |
EAX05432 EAX05433 Q8TC71 AB465501 BAJ53738 AB465502 BAJ53739 AI339078 AK057468 BAB71501 AK098625 BAC05356 AK304386 BAG65222 AK314799 BC025396 AAH25396 BC037886 AAH37886 BU683915 BU930386 CK904112 DC404003 XM_005265716 XP_005265773 XM_005265717 XP_005265774 XM_005265718 XP_005265775 XM_011534369 XP_011532671 XM_011534370 XP_011532672 XM_011534371 XP_011532673 XM_011534372 XP_011532674 XR_941044 NM_001297608 NP_001284537 NM_145263 NP_660306 NR_123728
|
| Function |
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. {ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}.
|
| Subcellular Location |
Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.
|
![Western Blot: SPATA18 Overexpression Lysate (Adult Normal) [NBL1-16377] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPATA18.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8498_SPATA18%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16377-img0002.jpg)