SPATA18

Gene Symbol SPATA18
Entrez Gene 132671
Alt Symbol Mieap, SPETEX1
Species Human
Gene Type protein-coding
Description spermatogenesis associated 18
Other Description mitochondria-eating protein|spermatogenesis associated 18 homolog|spermatogenesis-associated protein 18
Swissprots Q8N7D7 B4E2R0 Q8IY48 Q8TC71 E5RLK1
Accessions EAX05432 EAX05433 Q8TC71 AB465501 BAJ53738 AB465502 BAJ53739 AI339078 AK057468 BAB71501 AK098625 BAC05356 AK304386 BAG65222 AK314799 BC025396 AAH25396 BC037886 AAH37886 BU683915 BU930386 CK904112 DC404003 XM_005265716 XP_005265773 XM_005265717 XP_005265774 XM_005265718 XP_005265775 XM_011534369 XP_011532671 XM_011534370 XP_011532672 XM_011534371 XP_011532673 XM_011534372 XP_011532674 XR_941044 NM_001297608 NP_001284537 NM_145263 NP_660306 NR_123728
Function Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. {ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}.
Subcellular Location Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.

SPATA18 CRISPR/Cas9 KO Plasmid (h) - sc-407015 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 HDR Plasmid (h) - sc-407015-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 Double Nickase Plasmid (h) - sc-407015-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 Double Nickase Plasmid (h2) - sc-407015-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 CRISPR Activation Plasmid (h) - sc-407015-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 CRISPR Activation Plasmid (h2) - sc-407015-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 Lentiviral Activation Particles (h) - sc-407015-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 Lentiviral Activation Particles (h2) - sc-407015-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA18 siRNA (h) - sc-89204 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPATA18 shRNA Plasmid (h) - sc-89204-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPATA18 shRNA (h) Lentiviral Particles - sc-89204-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU046311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20415 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20415 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPATA18 siRNA (Human) - CRJ5097 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPATA18 - MBS8212574 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPATA18 (NM_145263.2) - SHH416060 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPATA18(NM_145263.2) - SHL026688 from Creative biogene

Category siRNA
Species Reactivities Human

SPATA18 shRNA Plasmid (Human) - CHJ5097 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPATA18 miRNA 3'UTR clone - MiUTR1H-09816 from Creative biogene

Species Reactivities Human
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