SPATA18

Gene Symbol	SPATA18
Entrez Gene	132671
Alt Symbol	Mieap, SPETEX1
Species	Human
Gene Type	protein-coding
Description	spermatogenesis associated 18
Other Description	mitochondria-eating protein|spermatogenesis associated 18 homolog|spermatogenesis-associated protein 18
Swissprots	Q8N7D7 B4E2R0 Q8IY48 Q8TC71 E5RLK1
Accessions	EAX05432 EAX05433 Q8TC71 AB465501 BAJ53738 AB465502 BAJ53739 AI339078 AK057468 BAB71501 AK098625 BAC05356 AK304386 BAG65222 AK314799 BC025396 AAH25396 BC037886 AAH37886 BU683915 BU930386 CK904112 DC404003 XM_005265716 XP_005265773 XM_005265717 XP_005265774 XM_005265718 XP_005265775 XM_011534369 XP_011532671 XM_011534370 XP_011532672 XM_011534371 XP_011532673 XM_011534372 XP_011532674 XR_941044 NM_001297608 NP_001284537 NM_145263 NP_660306 NR_123728
Function	Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. {ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}.
Subcellular Location	Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SPATA18 / MIEAP Antibody Blocking Peptide - LS-E2844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPATA18 / MIEAP Antibody Blocking Peptide - LS-E31205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SPATA18-Antibody-N-term-Blocking-peptide - BP13960a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPATA18 (N-term) Control Peptide - AP55600CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SPATA18 Peptide - 6615P from ProSci Category Peptide Species Human

Recombinant Human Mitochondria-eating protein(SPATA18) - CSB-YP840563HU CSB-EP840563HU CSB-BP840563HU CSB-MP840563HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SPATA18 - TP305544 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SPATA18 Protein - NBP1-81984PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SPATA18 Recombinant Protein Antigen - NBP2-48667PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

SPATA18 Peptide, Human - M34GP14978H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mitochondria-eating protein (SPATA18), Recombinant Protein - MBS1363126 from MyBioSource Category Protein Prices $1,330.00, $1,330.00, $1,550.00, $1,550.00, $2,200.00, $2,200.00, $2,665.00, $2,665.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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