| Gene Symbol |
HAS1
|
| Entrez Gene |
3036
|
| Alt Symbol |
HAS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hyaluronan synthase 1
|
| Other Description |
HA synthase 1|hyaluronate synthase 1|hyaluronic acid synthase 1
|
| Swissprots |
Q9NS49 Q14470 Q92839
|
| Accessions |
AAF87845 EAW72038 EAW72039 Q92839 AM904814 CAP17884 AY916554 AAY52130 AY916555 AAY52131 AY916556 AAY52132 BC035837 AAH35837 BX371636 D84424 BAA12351 DQ891219 ABM82145 DQ894402 ABM85328 U59269 AAC50706 XM_011526884 XP_011525186 NM_001297436 NP_001284365 NM_001523 NP_001514
|
| Function |
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine. {ECO:0000269|PubMed:8651928}.
|