| Gene Symbol | HAS1 |
|---|---|
| Entrez Gene | 3036 |
| Alt Symbol | HAS |
| Species | Human |
| Gene Type | protein-coding |
| Description | hyaluronan synthase 1 |
| Other Description | HA synthase 1|hyaluronate synthase 1|hyaluronic acid synthase 1 |
| Swissprots | Q9NS49 Q14470 Q92839 |
| Accessions | AAF87845 EAW72038 EAW72039 Q92839 AM904814 CAP17884 AY916554 AAY52130 AY916555 AAY52131 AY916556 AAY52132 BC035837 AAH35837 BX371636 D84424 BAA12351 DQ891219 ABM82145 DQ894402 ABM85328 U59269 AAC50706 XM_011526884 XP_011525186 NM_001297436 NP_001284365 NM_001523 NP_001514 |
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine. {ECO:0000269|PubMed:8651928}. |
HAS1 CRISPR/Cas9 KO Plasmid (h) - sc-401951 from Santa Cruz Biotechnology
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HAS1 HDR Plasmid (h) - sc-401951-HDR from Santa Cruz Biotechnology
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HAS1 Double Nickase Plasmid (h) - sc-401951-NIC from Santa Cruz Biotechnology
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HAS1 Double Nickase Plasmid (h2) - sc-401951-NIC-2 from Santa Cruz Biotechnology
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HAS1 CRISPR Activation Plasmid (h) - sc-401951-ACT from Santa Cruz Biotechnology
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HAS1 CRISPR Activation Plasmid (h2) - sc-401951-ACT-2 from Santa Cruz Biotechnology
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HAS1 Lentiviral Activation Particles (h) - sc-401951-LAC from Santa Cruz Biotechnology
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HAS1 Lentiviral Activation Particles (h2) - sc-401951-LAC-2 from Santa Cruz Biotechnology
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HAS1 siRNA (h) - sc-40690 from Santa Cruz Biotechnology
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HAS1 shRNA Plasmid (h) - sc-40690-SH from Santa Cruz Biotechnology
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HAS1 shRNA (h) Lentiviral Particles - sc-40690-V from Santa Cruz Biotechnology
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HAS1 siRNA (h2) - sc-156039 from Santa Cruz Biotechnology
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HAS1 shRNA Plasmid (h2) - sc-156039-SH from Santa Cruz Biotechnology
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HAS1 shRNA (h2) Lentiviral Particles - sc-156039-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9876 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9876 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01945 from Sigma-Aldrich
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HAS1 siRNA (Human) - CRH2064 from Cohesion Biosciences
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HAS1 - MBS829365 from MyBioSource
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shRNA set against Human HAS1 (NM_001523.2) - SHH310369 from Creative biogene
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shRNA set against Human HAS1(NM_001523.2) - SHH114239 from Creative biogene
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Human HAS1 siRNA - orb262566 from Biorbyt
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HAS1 shRNA Plasmid (Human) - CHH2064 from Cohesion Biosciences
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HAS1 miRNA 3'UTR clone - MiUTR1H-04379 from Creative biogene
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