| Gene Symbol |
MGAT4A
|
| Entrez Gene |
11320
|
| Alt Symbol |
GNT-IV, GNT-IVA, GnT-4a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
|
| Other Description |
N-acetylglucosaminyltransferase IVa|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa|UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa|UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A|alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase|glcNAc-T IVa|mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A
|
| Swissprots |
Q53S97 D3DVH6 Q9UM21 Q86Z15 B4E2R6 E9PEN2
|
| Accessions |
AAY14976 AAY24092 BAC55023 EAX01896 EAX01897 EAX01898 Q9UM21 AB000616 BAA86388 AK092952 AK128366 AK291533 BAF84222 AK304393 BAG65228 AK309852 AK314024 AW138839 BC127107 AAI27108 BC127108 AAI27109 NM_001160154 NP_001153626 NM_012214 NP_036346
|
| Function |
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
|
| Subcellular Location |
Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. {ECO:0000269|PubMed:10024668}.
|
| Top Pathways |
N-Glycan biosynthesis
|