MGAT4A

Gene Symbol MGAT4A
Entrez Gene 11320
Alt Symbol GNT-IV, GNT-IVA, GnT-4a
Species Human
Gene Type protein-coding
Description mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Other Description N-acetylglucosaminyltransferase IVa|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa|UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa|UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A|alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase|glcNAc-T IVa|mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A
Swissprots Q53S97 D3DVH6 Q9UM21 Q86Z15 B4E2R6 E9PEN2
Accessions AAY14976 AAY24092 BAC55023 EAX01896 EAX01897 EAX01898 Q9UM21 AB000616 BAA86388 AK092952 AK128366 AK291533 BAF84222 AK304393 BAG65228 AK309852 AK314024 AW138839 BC127107 AAI27108 BC127108 AAI27109 NM_001160154 NP_001153626 NM_012214 NP_036346
Function Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
Subcellular Location Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. {ECO:0000269|PubMed:10024668}.
Top Pathways N-Glycan biosynthesis

Human MGT4A protein fragment - ab161414 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161414 on a 12.5% SDS-PAGE stained with Coomassie Blue.

MGAT4A Partial Recombinant Protein - H00011320-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human MGAT4A Protein - NBP1-98960 from Novus Biologicals

Category Protein
Prices $269.00
Sizes 20 µg
Source E.coli
Species Human

MGAT4A - H00011320-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

MGAT4A - H00011320-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

MGAT4A fusion protein - Ag18956 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

MGAT4A fusion protein - Ag19003 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human MGAT4A, GST-tagged - MGAT4A-859H from Creative Biomart

Category Protein
Source E.coli
Species Human

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A(MGAT4A) - MBS1295052 from MyBioSource

Category Protein
Prices $2,195.00, $2,195.00, $2,660.00, $2,660.00
Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

MGAT4A Recombinant Protein Antigen - NBP1-81809PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

MGAT4A-Blocking-Peptide-N-Term - BP22052a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

MGAT4A Peptide, Human - M34GP09485H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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