NKIRAS2

Gene Symbol	NKIRAS2
Entrez Gene	28511
Alt Symbol	KBRAS2, kappaB-Ras2
Species	Human
Gene Type	protein-coding
Description	NFKB inhibitor interacting Ras-like 2
Other Description	I-kappa-B-interacting Ras-like protein 2\|NF-kappa-B inhibitor-interacting Ras-like protein 2\|NFKB inhibitor interacting Ras-like protein 2\|kappa B-Ras protein 2
Swissprots	B4DNM3 B3KNN0 Q9NSX1 Q6PK52 A6NCZ5 Q96KC7 Q9NYR9
Accessions	ABC40741 EAW60790 EAW60791 EAW60792 EAW60793 EAW60794 Q9NYR9 AF229840 AAF34999 AK027265 BAB55006 AK054571 BAG51392 AK297975 BAG60285 AL137682 CAB70873 BC007316 BC007450 AAH07450 BC009059 BC063498 AAH63498 BG717103 DA509824 DA607452 DQ893233 ABM84159 DQ896563 ABM87562 XM_005257251 XP_005257308 XM_011524680 XP_011522982 XM_011524681 XP_011522983 XM_011524682 XP_011522984 NM_001001349 NP_001001349 NM_001144927 NP_001138399 NM_001144928 NP_001138400 NM_001144929 NP_001138401 NM_017595 NP_060065
Function	Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Widely expressed. {ECO:0000269\|PubMed:10657303}.

Category	Cell Line
Species	Human

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