Gene Symbol | NKIRAS2 |
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Entrez Gene | 28511 |
Alt Symbol | KBRAS2, kappaB-Ras2 |
Species | Human |
Gene Type | protein-coding |
Description | NFKB inhibitor interacting Ras-like 2 |
Other Description | I-kappa-B-interacting Ras-like protein 2|NF-kappa-B inhibitor-interacting Ras-like protein 2|NFKB inhibitor interacting Ras-like protein 2|kappa B-Ras protein 2 |
Swissprots | B4DNM3 B3KNN0 Q9NSX1 Q6PK52 A6NCZ5 Q96KC7 Q9NYR9 |
Accessions | ABC40741 EAW60790 EAW60791 EAW60792 EAW60793 EAW60794 Q9NYR9 AF229840 AAF34999 AK027265 BAB55006 AK054571 BAG51392 AK297975 BAG60285 AL137682 CAB70873 BC007316 BC007450 AAH07450 BC009059 BC063498 AAH63498 BG717103 DA509824 DA607452 DQ893233 ABM84159 DQ896563 ABM87562 XM_005257251 XP_005257308 XM_011524680 XP_011522982 XM_011524681 XP_011522983 XM_011524682 XP_011522984 NM_001001349 NP_001001349 NM_001144927 NP_001138399 NM_001144928 NP_001138400 NM_001144929 NP_001138401 NM_017595 NP_060065 |
Function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10657303}. |
κB-Ras2 siRNA (h) - sc-41798 from Santa Cruz Biotechnology
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κB-Ras2 shRNA Plasmid (h) - sc-41798-SH from Santa Cruz Biotechnology
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κB-Ras2 shRNA (h) Lentiviral Particles - sc-41798-V from Santa Cruz Biotechnology
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NKIRAS2 RNAi - H00028511-R01 from Novus Biologicals
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NKIRAS2 RNAi - H00028511-R02 from Novus Biologicals
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MISSION® esiRNA - EHU133061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15324 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15324 from Sigma-Aldrich
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NKIRAS2 siRNA (Human) - CRH9117 from Cohesion Biosciences
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shRNA set against Human NKIRAS2 (NM_017595.5) - SHH352740 from Creative biogene
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NKIRAS2 shRNA Plasmid (Human) - CHH9117 from Cohesion Biosciences
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NKIRAS2 miRNA 3'UTR clone - MiUTR3H-06854 from Creative biogene
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NKIRAS2 miRNA 3'UTR clone - MiUTR3H-06855 from Creative biogene
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NKIRAS2 miRNA 3'UTR clone - MiUTR3H-06856 from Creative biogene
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NKIRAS2 miRNA 3'UTR clone - MiUTR3H-06857 from Creative biogene
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NKIRAS2 miRNA 3'UTR clone - MiUTR3H-06858 from Creative biogene
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