PSME3

Gene Symbol	PSME3
Entrez Gene	10197
Alt Symbol	HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Other Description	11S regulator complex gamma subunit|11S regulator complex subunit gamma|Ki antigen|Ki nuclear autoantigen|PA28 gamma variant 5|REG gamma-3|activator of multicatalytic protease subunit 3|epididymis secretory protein Li 283|proteasome activator 28 subunit gamma|proteasome activator 28-gamma|proteasome activator complex subunit 3
Swissprots	O35563 A8K9A3 P61289 Q9BQD9 Q12920 P97373 Q13172
Accessions	AAA93227 CAF86206 EAW60891 EAW60892 EAW60893 EAW60894 P61289 AI304773 AK057221 BAG51887 AK074999 BAG52046 AK292618 BAF85307 AK303211 BAH13919 AK307110 AK314347 BC001423 AAH01423 BC002684 AAH02684 BC008020 AAH08020 BG708969 BI464061 BQ005550 BT019386 AAV38193 BX640801 CAE45884 CR541745 CAG46545 DQ891930 ABM82856 DQ895117 ABM86043 EU794653 ACJ13707 FJ200488 ACO54885 JX156303 AFP49816 U11292 AAB60335 XM_011524177 XP_011522479 XM_011524178 XP_011522480 NM_001267045 NP_001253974 NM_005789 NP_005780 NM_176863 NP_789839 NR_049772
Function	Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:9325261}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.
Top Pathways	Proteasome, Hepatitis C, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PSME3 293T Cell Transient Overexpression Lysate(Denatured) - H00010197-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PSME3 overexpression lysate - LY406114 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PSME3 293 Cell Lysate - 403819 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PSME3 293 Cell Lysate - 407978 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PA28 Activator gamma Subunit/PSME3 Overexpression Lysate (Denatured) - H00010197-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PA28 Activator gamma Subunit/PSME3 Overexpression Lysate (Native) - NBL1-14909 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PSME3 Over-expression Lysate Product - GWB-C8C73A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PSME3 Over-expression Lysate Product - GWB-66B05C from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PA28 Activator gamma Subunit/PSME3 Overexpression Lysate (Native) - NBP2-05019 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human PSME3 Knockdown Stable Cell Line - CSC-DC012618 from Creative biogene Category Cell Line Species Human

PSME3 KO Cell Lysate-HEK293T - CLKO-0859 from Creative biogene Category Cell Lysate

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