PSME3

Gene Symbol	PSME3
Entrez Gene	10197
Alt Symbol	HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Other Description	11S regulator complex gamma subunit|11S regulator complex subunit gamma|Ki antigen|Ki nuclear autoantigen|PA28 gamma variant 5|REG gamma-3|activator of multicatalytic protease subunit 3|epididymis secretory protein Li 283|proteasome activator 28 subunit gamma|proteasome activator 28-gamma|proteasome activator complex subunit 3
Swissprots	O35563 A8K9A3 P61289 Q9BQD9 Q12920 P97373 Q13172
Accessions	AAA93227 CAF86206 EAW60891 EAW60892 EAW60893 EAW60894 P61289 AI304773 AK057221 BAG51887 AK074999 BAG52046 AK292618 BAF85307 AK303211 BAH13919 AK307110 AK314347 BC001423 AAH01423 BC002684 AAH02684 BC008020 AAH08020 BG708969 BI464061 BQ005550 BT019386 AAV38193 BX640801 CAE45884 CR541745 CAG46545 DQ891930 ABM82856 DQ895117 ABM86043 EU794653 ACJ13707 FJ200488 ACO54885 JX156303 AFP49816 U11292 AAB60335 XM_011524177 XP_011522479 XM_011524178 XP_011522480 NM_001267045 NP_001253974 NM_005789 NP_005780 NM_176863 NP_789839 NR_049772
Function	Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:9325261}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.
Top Pathways	Proteasome, Hepatitis C, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PSME3 full length protein - ab115714 from Abcam Category Protein Source E. coli Species Human

PSME3 peptide - ab4950 from Abcam Category Peptide

PSME3 Antibody Blocking Peptide - LS-E16830 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSME3 Antibody Blocking Peptide - LS-E16829 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSME3 Antibody Blocking Peptide - LS-E26330 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PA28 Activator gamma Subunit/PSME3 Recombinant Protein - H00010197-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PA28 Activator gamma Subunit/PSME3 Protein - NBP1-72541 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E. coli Species Human

PSME3 blocking peptide - GTX89066-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human His6-PA28 Activator gamma Subunit, CF - E-384-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal MSYY and 6-His tag

Recombinant human Proteasome activator complex subunit 3 protein (OPCA00997) - OPCA00997 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human PSME3 protein - orb245565 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PSME3 protein - orb169105 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human PSME3 protein (His Tag) - orb139539 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Goat anti PSME3 antibody Immunizing peptide - orb16835 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PSEM3 protein (His tag) - 80R-2044 from Fitzgerald Category Protein Prices $270.00 Sizes 50 µg Source E.coli

PSME3 Blocking Peptide - 33R-9372 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PSME3 Blocking Peptide - 33R-7157 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PSME3 Peptide - AC21-1165-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PSME3 (1-254, His-tag) - AR50127PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

PSME3 (1-254, His-tag) - AR50127PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

PSME3 - H00010197-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PSME3 - H00010197-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PSME3 control peptide - SP5365CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

PSME3, 1-254aa, Human, His tag, E.coli - 01-P1302 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

PSME3 fusion protein - Ag6702 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Search more