PSME3

Gene Symbol PSME3
Entrez Gene 10197
Alt Symbol HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
Species Human
Gene Type protein-coding
Description proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Other Description 11S regulator complex gamma subunit|11S regulator complex subunit gamma|Ki antigen|Ki nuclear autoantigen|PA28 gamma variant 5|REG gamma-3|activator of multicatalytic protease subunit 3|epididymis secretory protein Li 283|proteasome activator 28 subunit gamma|proteasome activator 28-gamma|proteasome activator complex subunit 3
Swissprots O35563 A8K9A3 P61289 Q9BQD9 Q12920 P97373 Q13172
Accessions AAA93227 CAF86206 EAW60891 EAW60892 EAW60893 EAW60894 P61289 AI304773 AK057221 BAG51887 AK074999 BAG52046 AK292618 BAF85307 AK303211 BAH13919 AK307110 AK314347 BC001423 AAH01423 BC002684 AAH02684 BC008020 AAH08020 BG708969 BI464061 BQ005550 BT019386 AAV38193 BX640801 CAE45884 CR541745 CAG46545 DQ891930 ABM82856 DQ895117 ABM86043 EU794653 ACJ13707 FJ200488 ACO54885 JX156303 AFP49816 U11292 AAB60335 XM_011524177 XP_011522479 XM_011524178 XP_011522480 NM_001267045 NP_001253974 NM_005789 NP_005780 NM_176863 NP_789839 NR_049772
Function Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:9325261}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.
Top Pathways Proteasome, Hepatitis C, Antigen processing and presentation

PA28γ CRISPR/Cas9 KO Plasmid (h) - sc-403397 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ HDR Plasmid (h) - sc-403397-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ Double Nickase Plasmid (h) - sc-403397-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ Double Nickase Plasmid (h2) - sc-403397-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ CRISPR Activation Plasmid (h) - sc-403397-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ CRISPR Activation Plasmid (h2) - sc-403397-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ Lentiviral Activation Particles (h) - sc-403397-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ Lentiviral Activation Particles (h2) - sc-403397-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PA28γ siRNA (h) - sc-106344 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PA28γ shRNA Plasmid (h) - sc-106344-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PA28γ shRNA (h) Lentiviral Particles - sc-106344-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PA28 Activator gamma Subunit/PSME3 RNAi - H00010197-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU041331 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17630 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17630 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PSME3 siRNA (Human) - CRH6886 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PA28 Activator gamma Subunit/PSME3 RNAi - H00010197-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PSME3 (NM_176863.2) - SHH385540 from Creative biogene

Category siRNA
Species Reactivities Human

Human PSME3 siRNA - orb267388 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PSME3 shRNA Plasmid (Human) - CHH6886 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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