| Gene Symbol |
LIME1
|
| Entrez Gene |
54923
|
| Alt Symbol |
LIME, dJ583P15.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Lck interacting transmembrane adaptor 1
|
| Other Description |
lck-interacting membrane protein|lck-interacting molecule|lck-interacting transmembrane adapter 1
|
| Swissprots |
Q6XYB3 Q9H400 E1P5K6 E1P5K5 Q9NX69 Q5JWJ2
|
| Accessions |
EAW75213 EAW75214 EAW75215 EAW75216 EAW75217 EAW75218 EAW75219 Q9H400 AI763397 AK000413 BAA91148 AK054722 AY203957 AAP34480 BC017016 AAH17016 BI911934 BP368475 NM_001305654 NP_001292583 NM_001305655 NP_001292584 NM_017806 NP_060276
|
| Function |
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}; Single-pass type III membrane protein {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
|
| Tissue Specificity |
Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level). {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046, ECO:0000269|PubMed:16160011}.
|