| Gene Symbol |
SIKE1
|
| Entrez Gene |
80143
|
| Alt Symbol |
SIKE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of IKBKE 1
|
| Other Description |
suppressor of IKK epsilon|suppressor of IKK-epsilon
|
| Swissprots |
Q9H778 Q68DZ4 Q9BRV8 Q5TEZ7 Q5TEZ9
|
| Accessions |
EAW56620 Q9BRV8 AI039175 AI221103 AK024821 BAB15020 AK126316 AK225734 BC005934 AAH05934 CR749219 CAH18076 CR936771 DA950119 DB459255 EU832701 ACE87033 NM_001102396 NP_001095866 NM_025073 NP_079349 NR_049741 NR_049742
|
| Function |
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269|PubMed:16281057}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16281057}.
|
| Tissue Specificity |
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269|PubMed:16281057}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|