Gene Symbol | SIKE1 |
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Entrez Gene | 80143 |
Alt Symbol | SIKE |
Species | Human |
Gene Type | protein-coding |
Description | suppressor of IKBKE 1 |
Other Description | suppressor of IKK epsilon|suppressor of IKK-epsilon |
Swissprots | Q9H778 Q68DZ4 Q9BRV8 Q5TEZ7 Q5TEZ9 |
Accessions | EAW56620 Q9BRV8 AI039175 AI221103 AK024821 BAB15020 AK126316 AK225734 BC005934 AAH05934 CR749219 CAH18076 CR936771 DA950119 DB459255 EU832701 ACE87033 NM_001102396 NP_001095866 NM_025073 NP_079349 NR_049741 NR_049742 |
Function | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269|PubMed:16281057}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16281057}. |
Tissue Specificity | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269|PubMed:16281057}. |
Top Pathways | RIG-I-like receptor signaling pathway |
SIKE CRISPR/Cas9 KO Plasmid (h) - sc-413345 from Santa Cruz Biotechnology
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SIKE HDR Plasmid (h) - sc-413345-HDR from Santa Cruz Biotechnology
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SIKE Double Nickase Plasmid (h) - sc-413345-NIC from Santa Cruz Biotechnology
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SIKE Double Nickase Plasmid (h2) - sc-413345-NIC-2 from Santa Cruz Biotechnology
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SIKE CRISPR Activation Plasmid (h) - sc-413345-ACT from Santa Cruz Biotechnology
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SIKE CRISPR Activation Plasmid (h2) - sc-413345-ACT-2 from Santa Cruz Biotechnology
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SIKE Lentiviral Activation Particles (h) - sc-413345-LAC from Santa Cruz Biotechnology
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SIKE Lentiviral Activation Particles (h2) - sc-413345-LAC-2 from Santa Cruz Biotechnology
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SIKE siRNA (h) - sc-88645 from Santa Cruz Biotechnology
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SIKE shRNA Plasmid (h) - sc-88645-SH from Santa Cruz Biotechnology
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SIKE shRNA (h) Lentiviral Particles - sc-88645-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19343 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19343 from Sigma-Aldrich
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SIKE1 siRNA (Human) - CRJ2768 from Cohesion Biosciences
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SIKE1 - MBS8225753 from MyBioSource
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shRNA set against Human SIKE (NM_025073.2) - SHH407552 from Creative biogene
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Human SIKE1 siRNA - orb273269 from Biorbyt
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SIKE1 shRNA Plasmid (Human) - CHJ2768 from Cohesion Biosciences
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SIKE1 miRNA 3'UTR clone - MiUTR1H-09398 from Creative biogene
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