SIKE1

Gene Symbol	SIKE1
Entrez Gene	80143
Alt Symbol	SIKE
Species	Human
Gene Type	protein-coding
Description	suppressor of IKBKE 1
Other Description	suppressor of IKK epsilon|suppressor of IKK-epsilon
Swissprots	Q9H778 Q68DZ4 Q9BRV8 Q5TEZ7 Q5TEZ9
Accessions	EAW56620 Q9BRV8 AI039175 AI221103 AK024821 BAB15020 AK126316 AK225734 BC005934 AAH05934 CR749219 CAH18076 CR936771 DA950119 DB459255 EU832701 ACE87033 NM_001102396 NP_001095866 NM_025073 NP_079349 NR_049741 NR_049742
Function	Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269|PubMed:16281057}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16281057}.
Tissue Specificity	Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269|PubMed:16281057}.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIKE1 full length protein - ab177720 from Abcam Category Protein Source E. coli Species Human

SIKE1 protein (His tag) - 80R-3751 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

SIKE1 / SIKE (1-207, His-tag) - AR51438PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

SIKE1 / SIKE (1-207, His-tag) - AR51438PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

SIKE1, 1-207aa Human, His tag, E.coli - 01-P2618 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

SIKE1 fusion protein - Ag18506 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SIKE1 fusion protein - Ag18196 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SIKE1, His-tagged - SIKE1-5122H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human SIKE1, His-tagged - SIKE1-2673H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human suppressor of IKBKE 1, His-tagged - SIKE1-521H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Suppressor of IKBKE 1(SIKE1) - CSB-YP887113HU CSB-EP887113HU CSB-BP887113HU CSB-MP887113HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SIKE1, 1-207aa, Human, His tag, E.coli - ATGP2618 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

Suppressor Of IKBKE 1 Protein (Recombinant) - abx263413 from Abbexa Category Protein

SIKE1 / SIKE (transcript variant 2) - TP303262 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SIKE1 Recombinant Protein Antigen - NBP1-82152PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SIKE1 Recombinant Protein Antigen - NBP1-82151PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SIKE-Blocking-Peptide-C-term - BP5375b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIKE1 Peptide, Human - M34GP14253H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human SIKE1 protein - orb260092 from Biorbyt Category Protein Prices $170.00, $289.00, $1,122.00 Sizes 2 μg, 10 μg, 100 μg Species Human

Recombinant Human SIKE1 Protein - NBP2-51631 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 20 µg, 100 µg Source E. coli Species Human

SIKE1 - PAT-82617-1 from Nordic BioSite Category Protein Species Human

SIKE1 - PAT-82617-2 from Nordic BioSite Category Protein Species Human

Suppressor Of IKBKE 1, Human Recombinant - 228-22021-1 from RayBiotech Category Protein Species Human

SIKE1, Recombinant Protein - MBS205734 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 20 µg, 100 µg Source E Coli Species Human

Suppressor Of IKBKE 1, Recombinant Protein - MBS146109 from MyBioSource Category Protein Prices $140.00, $205.00, $1,220.00 Sizes 2 µg, 10 µg, 100 µg Source E Coli

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