Gene Symbol | SIKE1 |
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Entrez Gene | 80143 |
Alt Symbol | SIKE |
Species | Human |
Gene Type | protein-coding |
Description | suppressor of IKBKE 1 |
Other Description | suppressor of IKK epsilon|suppressor of IKK-epsilon |
Swissprots | Q9H778 Q68DZ4 Q9BRV8 Q5TEZ7 Q5TEZ9 |
Accessions | EAW56620 Q9BRV8 AI039175 AI221103 AK024821 BAB15020 AK126316 AK225734 BC005934 AAH05934 CR749219 CAH18076 CR936771 DA950119 DB459255 EU832701 ACE87033 NM_001102396 NP_001095866 NM_025073 NP_079349 NR_049741 NR_049742 |
Function | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269|PubMed:16281057}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16281057}. |
Tissue Specificity | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269|PubMed:16281057}. |
Top Pathways | RIG-I-like receptor signaling pathway |
Anti-SIKE1 antibody - ab121860 from Abcam
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Anti-SIKE1 antibody - ab121795 from Abcam
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Anti-SIKE1 antibody [EPR14692] - ab183509 from Abcam
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Anti-SIKE1 antibody [EPR14692-1] - ab186418 from Abcam
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Anti-SIKE1 antibody - N-terminal - ab199877 from Abcam
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Anti-SIKE1 Antibody (aa36-63) - LS-C325116 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182) - LS-C161095 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182, AP) - LS-C224069 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182, APC) - LS-C224071 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182, Biotin) - LS-C224072 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182, FITC) - LS-C224073 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182, PE) - LS-C224074 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63) - LS-C157933 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa154-182, Azide-free, HRP) - LS-C224075 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63, AP) - LS-C224076 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63, Biotin) - LS-C224078 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63, FITC) - LS-C224079 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63, APC) - LS-C224077 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63, Azide-free, HRP) - LS-C224080 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa36-63, PE) - LS-C224081 from LifeSpan Bioscience
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Anti-SIKE1 Antibody (aa161-190) - LS-C325114 from LifeSpan Bioscience
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SIKE1 Antibody - NBP1-82152 from Novus Biologicals
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SIKE1 Antibody - NBP1-82151 from Novus Biologicals
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ANTI-SIKE(C-TERMINAL) antibody produced in rabbit - SAB1306322 from Sigma-Aldrich
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Anti-SIKE1 antibody produced in rabbit - HPA024177 from Sigma-Aldrich
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