Gene Symbol | ADHFE1 |
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Entrez Gene | 137872 |
Alt Symbol | ADH8, HMFT2263, HOT |
Species | Human |
Gene Type | protein-coding |
Description | alcohol dehydrogenase, iron containing, 1 |
Other Description | Fe-containing alcohol dehydrogenase 1|alcohol dehydrogenase 8|alcohol dehydrogenase iron-containing protein 1|hydroxyacid-oxoacid transhydrogenase, mitochondrial |
Swissprots | Q6P2B6 Q96MF9 B4DTJ8 Q68CI7 Q49A19 Q8IWW8 |
Accessions | EAW86901 EAW86902 EAW86903 EAW86904 EAW86905 EAW86906 EAW86907 Q8IWW8 AB075879 BAD38661 AK056992 BAB71335 AK293530 BAG57012 AK294114 BAG57448 AK300243 BAG62010 AK300881 BAG62523 AY033237 AAK44223 BC047492 BC064634 AAH64634 BC110290 BE241883 BG698892 BQ182872 CB157325 NM_144650 NP_653251 |
Function | Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. {ECO:0000269|PubMed:16435184}. |
Subcellular Location | Mitochondrion {ECO:0000250}. |
Tissue Specificity | Only expressed in adult liver. {ECO:0000269|PubMed:12592711}. |
ADH8 (F-9) - sc-390387 from Santa Cruz Biotechnology
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ADH8 (B-10) - sc-390552 from Santa Cruz Biotechnology
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ADH8 (D-13) - sc-87544 from Santa Cruz Biotechnology
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ADH8 (H-240) - sc-292533 from Santa Cruz Biotechnology
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ADH8 (K-14) - sc-87545 from Santa Cruz Biotechnology
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ADH8 (S-16) - sc-87546 from Santa Cruz Biotechnology
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Anti-ADHFE1 antibody - ab198734 from Abcam
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Anti-ADHFE1 antibody - ab102600 from Abcam
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Anti-ADHFE1 antibody - ab84313 from Abcam
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Anti-ADHFE1 antibody - ab70868 from Abcam
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Anti-ADHFE1 antibody [EPR12501] - ab173530 from Abcam
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Anti-ADHFE1 Antibody - LS-C309339 from LifeSpan Bioscience
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Anti-ADHFE1 Antibody - LS-C306113 from LifeSpan Bioscience
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Anti-ADHFE1 Antibody (aa288-337) - LS-C102455 from LifeSpan Bioscience
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ADHFE1 Antibody - NBP1-83530 from Novus Biologicals
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ADHFE1 Antibody - NBP2-15298 from Novus Biologicals
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ADHFE1 Antibody - NBP2-15297 from Novus Biologicals
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ADHFE1 Antibody - H00137872-A01 from Novus Biologicals
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ADHFE1 Antibody - H00137872-B01P from Novus Biologicals
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ADHFE1 Antibody - H00137872-D01P from Novus Biologicals
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Anti-ADHFE1 antibody produced in mouse - SAB1408329 from Sigma-Aldrich
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Anti-ADHFE1 antibody produced in rabbit - SAB1410235 from Sigma-Aldrich
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Anti-ADHFE1 antibody produced in rabbit - SAB2100061 from Sigma-Aldrich
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Anti-ADHFE1 antibody produced in rabbit - HPA023062 from Sigma-Aldrich
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ADHFE1 antibody - middle region (ARP52720_P050) - ARP52720_P050 from Aviva Systems Biology
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