| Gene Symbol |
ADHFE1
|
| Entrez Gene |
137872
|
| Alt Symbol |
ADH8, HMFT2263, HOT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alcohol dehydrogenase, iron containing, 1
|
| Other Description |
Fe-containing alcohol dehydrogenase 1|alcohol dehydrogenase 8|alcohol dehydrogenase iron-containing protein 1|hydroxyacid-oxoacid transhydrogenase, mitochondrial
|
| Swissprots |
Q6P2B6 Q96MF9 B4DTJ8 Q68CI7 Q49A19 Q8IWW8
|
| Accessions |
EAW86901 EAW86902 EAW86903 EAW86904 EAW86905 EAW86906 EAW86907 Q8IWW8 AB075879 BAD38661 AK056992 BAB71335 AK293530 BAG57012 AK294114 BAG57448 AK300243 BAG62010 AK300881 BAG62523 AY033237 AAK44223 BC047492 BC064634 AAH64634 BC110290 BE241883 BG698892 BQ182872 CB157325 NM_144650 NP_653251
|
| Function |
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. {ECO:0000269|PubMed:16435184}.
|
| Subcellular Location |
Mitochondrion {ECO:0000250}.
|
| Tissue Specificity |
Only expressed in adult liver. {ECO:0000269|PubMed:12592711}.
|