RORC

Gene Symbol RORC
Entrez Gene 6097
Alt Symbol NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Species Human
Gene Type protein-coding
Description RAR-related orphan receptor C
Other Description RAR-related orphan nuclear receptor variant 2|nuclear receptor ROR-gamma|nuclear receptor RZR-gamma|nuclear receptor subfamily 1 group F member 3|retinoic acid-binding receptor gamma|retinoid-related orphan receptor gamma
Swissprots P51449 Q5SZR9 Q8N5V7 Q8NCY8
Accessions EAW53405 EAW53406 P51449 AB307696 BAH02287 AF075096 AK097994 BAG53561 AK128522 AK223137 BAD96857 AK298460 BAG60673 AK315662 BAG38028 AL834219 CAD38900 AM393818 CAL38693 AM393876 CAL38751 AW004872 BC031554 AAH31554 BC110571 AAI10572 BI520481 CB161467 CR457436 CAG33717 DQ890805 ABM81731 DQ893960 ABM84886 HQ692834 ADZ17345 U16997 AAA64751 XM_006711484 XP_006711547 XR_426792 NM_001001523 NP_001001523 NM_005060 NP_005051
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue- selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, C
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Top Pathways Circadian rhythm, Inflammatory bowel disease (IBD)

RORγ (D-4) - sc-365476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RORγ (D-4): sc-365476. Western blot analysis of RORγ expression in non-transfected: sc-117752 (A) and human RORγ transfected: sc-158936 (B) 293T whole cell lysates.

RORγ (27.92) - sc-293150 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

RORγ (G-16) - sc-26412 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RORγ (G-16): sc-26412. Western blot analysis of RORγ expression in non-transfected: sc-117752 (A) and human RORγ transfected: sc-170801 (B) 293T whole cell lysates.

RORγ (H-190) - sc-28559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RORγ (H-190): sc-28559. Western blot analysis of RORγ expression in rat skeletal muscle tissue extract.

RORγ (K-20) - sc-14196 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RORγ (S-14) - sc-26411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RORγ (S-14): sc-26411. Western blot analysis of RORγ expression in non-transfected: sc-117752 (A) and human RORγ transfected: sc-170801 (B) 293T whole cell lysates.

RORγ (162C2a) - sc-81371 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RORγ (162C2a): sc-81371. Western blot analysis of RORγ expression in non-transfected: sc-117752 (A) and human RORγ transfected: sc-114336 (B) 293T whole cell lysates.

Anti-ROR gamma antibody - ab78007 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue, staining ROR gamma with ab78007 at 10 µg/ml.

Anti-ROR gamma antibody - ab80690 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ROR gamma antibody (ab80690) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-ROR gamma antibody - ab113434 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-ROR gamma antibody (ab113434) at 0.1 µg/ml + Human Colon lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-ROR gamma antibody - ab74703 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ROR gamma antibody (ab74703) at 1 µg/mlLane 1 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 2 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-ROR gamma antibody - ab138043 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ROR gamma antibody (ab138043) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-ROR gamma antibody - ab137775 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ROR gamma antibody (ab137775) at 1/1000 dilution + H1299 cell lysate at 30 µg

Anti-ROR gamma antibody [162C2a] - ab58670 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 162C2a
Anti-ROR gamma antibody [162C2a] (ab58670) + immunising recombinant protein

Anti-ROR gamma antibody [4G419] (Phycoerythrin) - ab104950 from Abcam

Prices $376.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 4G419
ab104950 at 10 µl per 1x106 cells (0.25 ug) staining ROR gamma in Human lymphocytes by Intracellular flow cytometric analysis. Shaded histogram represents cells without antibody; green represents isotype control; red represents ab104950.

Anti-ROR gamma antibody [4G419], prediluted (FITC) - ab104906 from Abcam

Prices $376.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 4G419
Intracellular flow cytometric analysis of ROR gamma in Human lymphocytes using 10&microl (0.25 ug) of ab104906. Shaded histogram represents cells without antibody; green represents isotype control; red represents ab104906.

Anti-ROR gamma antibody [EPR13056] - ab180173 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13056
All lanes : Anti-ROR gamma antibody [EPR13056] (ab180173) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal thymus lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labeled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-ROR gamma antibody [H6437] - ab41941 from Abcam

Host Mouse
Clonality Monoclonal
Clone H6437

Anti-RORC / ROR Gamma Antibody (aa212-461) - LS-C296184 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RORC / ROR Gamma.

Anti-RORC / ROR Gamma Antibody (clone 1G7) - LS-C198102 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G7
RORC monoclonal antibody (M01), clone 1G7. Western Blot analysis of RORC expression in human kidney.

Anti-RORC / ROR Gamma Antibody (Internal) - LS-C345259 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of RORC Antibody with MCF7 Whole Cell lysate.

Anti-RORC / ROR Gamma Antibody (aa1-50) IHC-plus™ - LS-B1797 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ROR Gamma antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1797 concentration 10 ug/ml.

Anti-RORC / ROR Gamma Antibody (aa1-50, clone 4G419) - LS-C148460 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G419
Western blot of ROR

Anti-RORC / ROR Gamma Antibody (clone 162C2a) - LS-C342609 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 162C2a
Western blot analysis of immunized recombinant protein, using anti-RORC monoclonal antibody.

Anti-RORC / ROR Gamma Antibody (Ligand-binding Domain) IHC-plus™ - LS-A5191 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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