RORC

Gene Symbol	RORC
Entrez Gene	6097
Alt Symbol	NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Species	Human
Gene Type	protein-coding
Description	RAR-related orphan receptor C
Other Description	RAR-related orphan nuclear receptor variant 2|nuclear receptor ROR-gamma|nuclear receptor RZR-gamma|nuclear receptor subfamily 1 group F member 3|retinoic acid-binding receptor gamma|retinoid-related orphan receptor gamma
Swissprots	P51449 Q5SZR9 Q8N5V7 Q8NCY8
Accessions	EAW53405 EAW53406 P51449 AB307696 BAH02287 AF075096 AK097994 BAG53561 AK128522 AK223137 BAD96857 AK298460 BAG60673 AK315662 BAG38028 AL834219 CAD38900 AM393818 CAL38693 AM393876 CAL38751 AW004872 BC031554 AAH31554 BC110571 AAI10572 BI520481 CB161467 CR457436 CAG33717 DQ890805 ABM81731 DQ893960 ABM84886 HQ692834 ADZ17345 U16997 AAA64751 XM_006711484 XP_006711547 XR_426792 NM_001001523 NP_001001523 NM_005060 NP_005051
Function	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue- selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, C
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Top Pathways	Circadian rhythm, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ROR gamma full length protein - ab159369 from Abcam Category Protein Source Wheat germ Species Human

Human ROR gamma peptide - ab87126 from Abcam Category Peptide

Human ROR gamma protein fragment - ab159370 from Abcam Category Protein Source Wheat germ Species Human

RORC / ROR Gamma Antibody Blocking Peptide - LS-E2707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E27620 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E29047 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RORC / ROR Gamma Blocking Peptide - LS-E29048 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E29049 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E29050 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E29051 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E11721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E21296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E16654 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RORC / ROR Gamma Antibody Blocking Peptide - LS-E35714 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human ROR gamma/RORC/NR1F3 Protein - H00006097-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RORC-Antibody-Center-Blocking-peptide - BP13786c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RORC Protein Lysate (APL10238) - APL10238 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

RORC Protein (OPPA00193) - OPPA00193 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human RORC protein - orb244500 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RORC protein - orb169206 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

RORC Blocking Peptide - 33R-2655 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human RORg Protein - abx068825 from Abbexa Category Protein Source E.coli Species Human

ROR gamma Peptide - AC21-2437-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ROR-gamma / RORC - H00006097-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ROR-gamma / RORC - H00006097-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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