RORC

Gene Symbol	RORC
Entrez Gene	6097
Alt Symbol	NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Species	Human
Gene Type	protein-coding
Description	RAR-related orphan receptor C
Other Description	RAR-related orphan nuclear receptor variant 2|nuclear receptor ROR-gamma|nuclear receptor RZR-gamma|nuclear receptor subfamily 1 group F member 3|retinoic acid-binding receptor gamma|retinoid-related orphan receptor gamma
Swissprots	P51449 Q5SZR9 Q8N5V7 Q8NCY8
Accessions	EAW53405 EAW53406 P51449 AB307696 BAH02287 AF075096 AK097994 BAG53561 AK128522 AK223137 BAD96857 AK298460 BAG60673 AK315662 BAG38028 AL834219 CAD38900 AM393818 CAL38693 AM393876 CAL38751 AW004872 BC031554 AAH31554 BC110571 AAI10572 BI520481 CB161467 CR457436 CAG33717 DQ890805 ABM81731 DQ893960 ABM84886 HQ692834 ADZ17345 U16997 AAA64751 XM_006711484 XP_006711547 XR_426792 NM_001001523 NP_001001523 NM_005060 NP_005051
Function	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue- selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, C
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Top Pathways	Circadian rhythm, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RORC / ROR Gamma ELISA Kit (Sandwich ELISA) - LS-F8765 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

Rat RORC / ROR Gamma ELISA Kit (Sandwich ELISA) - LS-F9734 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.156-10 ng/ml

Nuclear receptor ROR-gamma (RORC), Human, ELISA Kit - CSB-EL020071HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Nuclear receptor ROR-gamma, RORC, Human, ELISA Kit - E10640h from ARP American Research Products Category ELISA Kit Prices $436.00 Sizes 96 t Range 0.156-10 ng/mL

RAR Related Orphan Receptor Gamma (RORg), Human, ELISA Kit - SED949Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.071ng/mL Range 0.156-10ng/mL

Nuclear receptor ROR-gamma (RORC), ELISA Kit - MBS9306626 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RAR-related orphan receptor C, ELISA Kit - MBS911044 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.12 pg/ml. Range 12.5 pg/ml -800 pg/ml.

ELISA Kit for RAR Related Orphan Receptor Gamma (RORg) - SED949Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for RAR Related Orphan Receptor Gamma (RORg) - SED949Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Nuclear receptor ROR-gamma(RORC) ELISA kit - CSB-EL020071HU from Cusabio Category ELISA Kit Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

ELISA Kit for RAR Related Orphan Receptor Gamma (RORg) - SED949Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse RORC / ROR Gamma ELISA Kit (Custom ELISA) - LS-F15857 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Nuclear receptor ROR-gamma ELISA Kit - abx253463 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human RORg ELISA Kit - abx152980 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

RAR Related Orphan Receptor Gamma (RORg), Human, ELISA Kit - DL-RORg-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human RORg ELISA Kit - abx571519 from Abbexa Category ELISA Kit Sensitivity 0.071 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Nuclear receptor ROR-gamma (RORC) ELISA Kit - EKC34858 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

Human Nuclear receptor ROR-gamma ELISA Kit - EKE51136 from Biomatik Category ELISA Kit Prices $501.40, $2,130.95, $4,011.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/mL

RORC - EKH0988 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

RORC ELISA Kit (Human) : 96 Wells (OKEH02106) - OKEH02106 from Aviva Systems Biology Category ELISA Kit Prices $330.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

RORC - EKH988 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human RORg ELISA Kit - E032831 from Biobool Category ELISA Kit Sensitivity Typically less than 0.058ng/mL.

Human RORC ELISA Kit - E032834 from Biobool Category ELISA Kit Sensitivity 3.12 pg/ml.

Human Nuclear receptor ROR-gamma ELISA Kit - EK2672 from Signalway Antibody Category ELISA Kit Prices $439.00 Sizes 1x96t Sensitivity less than 0.078 ng/mL Range 0.156-10 ng/mL

Nuclear Receptor ROR-Gamma (RORG), ELISA Kit - MBS9354615 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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