RORC

Gene Symbol	RORC
Entrez Gene	6097
Alt Symbol	NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Species	Human
Gene Type	protein-coding
Description	RAR-related orphan receptor C
Other Description	RAR-related orphan nuclear receptor variant 2|nuclear receptor ROR-gamma|nuclear receptor RZR-gamma|nuclear receptor subfamily 1 group F member 3|retinoic acid-binding receptor gamma|retinoid-related orphan receptor gamma
Swissprots	P51449 Q5SZR9 Q8N5V7 Q8NCY8
Accessions	EAW53405 EAW53406 P51449 AB307696 BAH02287 AF075096 AK097994 BAG53561 AK128522 AK223137 BAD96857 AK298460 BAG60673 AK315662 BAG38028 AL834219 CAD38900 AM393818 CAL38693 AM393876 CAL38751 AW004872 BC031554 AAH31554 BC110571 AAI10572 BI520481 CB161467 CR457436 CAG33717 DQ890805 ABM81731 DQ893960 ABM84886 HQ692834 ADZ17345 U16997 AAA64751 XM_006711484 XP_006711547 XR_426792 NM_001001523 NP_001001523 NM_005060 NP_005051
Function	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue- selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, C
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Top Pathways	Circadian rhythm, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RORC transcript variant 1 Gene cDNA Clone - orb145098 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-RORC-cDNA-Clone - DC06250 from Abgent, a WuXi AppTec company Prices $699.30 Sizes 10 µg Species Human Accession BC031554

RORC cDNA (ANA10238) - ANA10238 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC031554

RORC - MBS1268799 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC031554

Human RORC cDNA clone(NM_001001523.1) - CDFH016489 from Creative Biomart Species Human Accession NM_001001523.1

Human RORC cDNA clone(NM_005060.3) - CDFH016490 from Creative Biomart Species Human Accession NM_005060.3

Human RORC ORF clone(NM_005060.3) - CDCL186002 from Creative Biomart Species Human Accession NM_005060.3

Human RORC ORF Clone(NM_005060.3) - CDCR289245 from Creative Biomart Species Human Accession NM_005060.3

Human RORC ORF Clone(NM_005060.3) - CDCR289246 from Creative Biomart Species Human Accession NM_005060.3

Human RORC ORF Clone(NM_005060.3) - CDCR289247 from Creative Biomart Species Human Accession NM_005060.3

Human RORC ORF Clone(NM_001001523.1) - CDCR338297 from Creative Biomart Species Human Accession NM_001001523.1

Human RORC ORF Clone(NM_001001523.1) - CDCR338298 from Creative Biomart Species Human Accession NM_001001523.1

Human RORC transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10718-U from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10718-U-F from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10718-CH from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10718-ANG from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10718-ACR from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10718-ANR from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10718-U-N from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10718-UT from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10718-ACG from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10718-NH from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10718-NF from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10718-NM from Sino Biological Species Human

Human RORC transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10718-CF from Sino Biological Species Human

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