| Gene Symbol |
KHDRBS3
|
| Entrez Gene |
10656
|
| Alt Symbol |
Etle, SALP, SLM-2, SLM2, T-STAR, TSTAR, etoile
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KH domain containing, RNA binding, signal transduction associated 3
|
| Other Description |
KH domain-containing, RNA-binding, signal transduction-associated protein 3|RNA-binding protein T-Star|Sam68-like phosphotyrosine protein, T-STAR|sam68-like mammalian protein 2
|
| Swissprots |
Q9UPA8 Q6NUL8 O75525
|
| Accessions |
CCQ43363 EAW92182 O75525 AF051321 AAC99294 AF051322 AAC99295 AF069681 AAC24857 BC032606 AAH32606 BC068536 AAH68536 BX537666 CB155439 DQ890886 ABM81812 DQ894041 ABM84967 XM_005250757 XP_005250814 XM_005250758 XP_005250815 XM_011516796 XP_011515098 XM_011516797 XP_011515099 XM_011516798 XP_011515100 XM_011516799 XP_011515101 XR_242372 XR_242374 XR_928287 NM_006558 NP_006549
|
| Function |
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. {ECO:0000269|PubMed:10564820, ECO:0000269|PubMed:11741900, ECO:0000269|PubMed:15901763}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10332027, ECO:0000269|PubMed:15901763}. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
|
| Tissue Specificity |
Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. {ECO:0000269|PubMed:10077576, ECO:0000269|PubMed:10332027, ECO:0000269|PubMed:10564820}.
|