| Gene Symbol |
MIEF2
|
| Entrez Gene |
125170
|
| Alt Symbol |
MID49, SMCR7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial elongation factor 2
|
| Other Description |
Smith-Magenis syndrome chromosomal region candidate gene 7 protein|Smith-Magenis syndrome chromosome region, candidate 7|mitochondrial dynamic protein MID49|mitochondrial dynamic protein of 49 kDa|mitochondrial dynamics protein MID49|mitochondrial dynamics protein of 49 kDa
|
| Swissprots |
Q96N07 Q96C03 Q6ZRD4 J3KPT3
|
| Accessions |
CCQ43835 EAW55651 EAW55652 Q96C03 AF467443 AAL78340 AK056165 BAB71108 AK128310 BAC87377 BC014973 AAH14973 BC035292 DB183618 JF432161 ADZ15378 NM_001144900 NP_001138372 NM_139162 NP_631901 NM_148886 NP_683684
|
| Function |
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:21508961}; Single-pass membrane protein {ECO:0000269|PubMed:21508961}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
|
| Tissue Specificity |
Expressed in all tissues tested with highest expression in heart and skeletal muscle. {ECO:0000269|PubMed:11997338}.
|
![Western Blot: SMCR7 Overexpression Lysate (Adult Normal) [NBP2-05587] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMCR7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5435_SMCR7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05587-img0001.jpg)