Gene Symbol | MIEF2 |
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Entrez Gene | 125170 |
Alt Symbol | MID49, SMCR7 |
Species | Human |
Gene Type | protein-coding |
Description | mitochondrial elongation factor 2 |
Other Description | Smith-Magenis syndrome chromosomal region candidate gene 7 protein|Smith-Magenis syndrome chromosome region, candidate 7|mitochondrial dynamic protein MID49|mitochondrial dynamic protein of 49 kDa|mitochondrial dynamics protein MID49|mitochondrial dynamics protein of 49 kDa |
Swissprots | Q96N07 Q96C03 Q6ZRD4 J3KPT3 |
Accessions | CCQ43835 EAW55651 EAW55652 Q96C03 AF467443 AAL78340 AK056165 BAB71108 AK128310 BAC87377 BC014973 AAH14973 BC035292 DB183618 JF432161 ADZ15378 NM_001144900 NP_001138372 NM_139162 NP_631901 NM_148886 NP_683684 |
Function | Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378}. |
Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:21508961}; Single-pass membrane protein {ECO:0000269|PubMed:21508961}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria. |
Tissue Specificity | Expressed in all tissues tested with highest expression in heart and skeletal muscle. {ECO:0000269|PubMed:11997338}. |
SMCR7 (C-15) - sc-165504 from Santa Cruz Biotechnology
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Anti-SMCR7 antibody - ab101350 from Abcam
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Anti-SMCR7 antibody - N-terminal - ab182535 from Abcam
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Anti-MIEF2 / SMCR7 Antibody (aa15-64) - LS-C206003 from LifeSpan Bioscience
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Anti-MIEF2 / SMCR7 Antibody (aa51-100) - LS-C206004 from LifeSpan Bioscience
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SMCR7 Antibody - NBP1-81165 from Novus Biologicals
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SMCR7 Antibody - NBP2-20421 from Novus Biologicals
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Anti-SMCR7 antibody produced in rabbit - HPA042334 from Sigma-Aldrich
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Anti-SMCR7 antibody produced in rabbit - SAB2700654 from Sigma-Aldrich
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SMCR7 Antibody - N-terminal region (ARP71640_P050) - ARP71640_P050 from Aviva Systems Biology
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SMCR7 Antibody - N-terminal region (ARP71641_P050) - ARP71641_P050 from Aviva Systems Biology
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SMCR7 antibody - 16413-1-AP from Acris Antibodies
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SMCR7/MID49 antibody - 16413-1-AP from Proteintech Group
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Anti-SMCR7 (aa 15-64) polyclonal antibody - DPABH-14089 from Creative Diagnostics
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SMCR7 - MBS270881 from MyBioSource
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SMCR7-Antibody-N-terminal-region-AI15972 - AI15972 from Abgent, a WuXi AppTec company
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MIEF2 - A9185 from NeoScientific
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MIEF2 Polyclonal Antibody - A9185 from ABclonal
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SMCR7 Antibody - abx124872 from Abbexa
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SMCR7 antibody - TA331633 from Acris Antibodies
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SMCR7 antibody - TA331634 from Acris Antibodies
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Anti-MIEF2 polyclonal antibody - CABT-BL4046 from Creative Diagnostics
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anti-SMCR7,MID49 antibody - A008022 from Biobool
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SMCR7 Antibody - N-terminal region : Biotin (ARP71640_P050-Biotin) - ARP71640_P050-Biotin from Aviva Systems Biology
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SMCR7 Antibody - N-terminal region : FITC (ARP71640_P050-FITC) - ARP71640_P050-FITC from Aviva Systems Biology
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