NOTCH3

Gene Symbol	NOTCH3
Entrez Gene	4854
Alt Symbol	CADASIL, CASIL, IMF2
Species	Human
Gene Type	protein-coding
Description	notch 3
Other Description	Notch homolog 3|neurogenic locus notch homolog protein 3
Swissprots	Q9UEB3 Q9Y6L8 Q9UM47 Q9UPL3
Accessions	AAC04897 AAC14346 AAC15789 ACL52278 CAA55955 EAW84466 Q9UM47 AB209447 BAD92684 DQ156540 DQ156541 DQ156542 DQ156543 U97669 AAB91371 XM_005259924 XP_005259981 NM_000435 NP_000426
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitously expressed in fetal and adult tissues.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human NOTCH3 ELISA Kit (Sandwich ELISA) - LS-F12175 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Neurogenic locus notch homolog protein 3 (NOTCH3), Human, ELISA Kit - CSB-EL015952HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Neurogenic locus notch homolog protein 3, NOTCH3, Human, ELISA Kit - E3908h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

Custom Human Notch-3 ELISA - ELH-NOTCH3 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Neurogenic locus notch homolog protein 3, NOTCH3, ELISA Kit - MBS9307147 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neurogenic locus notch homolog protein 3, NOTCH3, ELISA Kit - MBS9307020 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch homolog 3 (Drosophila) , ELISA Kit - MBS928424 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human NOTCH3 is typically less than 31.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 125 pg/ml-8000 pg/ml.

Human Neurogenic locus notch homolog protein 3(NOTCH3) ELISA kit - CSB-EL015952HU from Cusabio Category ELISA Kit Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Mouse NOTCH3 ELISA Kit (Custom ELISA) - LS-F19912 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat NOTCH3 ELISA Kit (Custom ELISA) - LS-F19913 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Custom Human Notch-3 Elisa kit - orb305353 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

Human Notch-3 ELISA - RAB1603 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Notch Homolog 3 (NOTCH3) ELISA Kit - EKU09300 from Biomatik Category ELISA Kit Prices $809.00, $3,557.00, $6,468.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.055 ng/mL Range 0.156-10 ng/mL

NOTCH3 - EKH4570 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

NOTCH3 ELISA Kit (Human) : 96 Wells (OKEH01723) - OKEH01723 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 0.054 ng/mL Range 0.156 - 10 ng/mL

Custom Human Notch-3 ELISA - ELH-NOTCH3-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human NOTCH3 ELISA Kit - E026797 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human NOTCH3 is typically less than 31.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

Human Neurogenic locus notch homolog protein 3 ELISA Kit - EK4619 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 31pg/mL Range 78-5000 pg/mL

anti-NOTCH3 antibody - ARG63870 from Arigo Biolaboratories Category ELISA Kit

Neurogenic locus notch homolog protein 3, ELISA Kit - MBS2883586 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Neurogenic locus notch homolog protein 3, ELISA Kit - MBS762554 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Neurogenic locus notch homolog protein 3, ELISA Kit - MBS9428445 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 0.054ng/mL Range 0.156-10 ng/mL

Notch Homolog 3, ELISA Kit - MBS2033654 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.055ng/mL. Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.

Human NOTCH3 ELISA Kit (Sandwich ELISA) - LS-F35853 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

Human NOTCH3 ELISA Kit (Sandwich ELISA) - LS-F39099 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.055 Range 0.156-10 ng/ml

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