NOTCH3

Gene Symbol	NOTCH3
Entrez Gene	4854
Alt Symbol	CADASIL, CASIL, IMF2
Species	Human
Gene Type	protein-coding
Description	notch 3
Other Description	Notch homolog 3|neurogenic locus notch homolog protein 3
Swissprots	Q9UEB3 Q9Y6L8 Q9UM47 Q9UPL3
Accessions	AAC04897 AAC14346 AAC15789 ACL52278 CAA55955 EAW84466 Q9UM47 AB209447 BAD92684 DQ156540 DQ156541 DQ156542 DQ156543 U97669 AAB91371 XM_005259924 XP_005259981 NM_000435 NP_000426
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitously expressed in fetal and adult tissues.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Notch 3 CRISPR/Cas9 KO Plasmid (h) - sc-400424 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 HDR Plasmid (h) - sc-400424-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 Double Nickase Plasmid (h) - sc-400424-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 Double Nickase Plasmid (h2) - sc-400424-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 CRISPR Activation Plasmid (h) - sc-400424-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 CRISPR Activation Plasmid (h2) - sc-400424-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 Lentiviral Activation Particles (h) - sc-400424-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 Lentiviral Activation Particles (h2) - sc-400424-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Notch 3 siRNA (h) - sc-37135 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Notch 3 shRNA Plasmid (h) - sc-37135-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Notch 3 shRNA (h) Lentiviral Particles - sc-37135-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU055111 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1427 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1429 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1428 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1708 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1708 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1429 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1428 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1427 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07514 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07514

NOTCH3 siRNA (Human) - CRH3226 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Notch-3 RNAi - H00004854-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human NOTCH3 (NM_000435.2) - SHH353844 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NOTCH3(NM_000435.2) - SHR008724 from Creative biogene Category siRNA Species Reactivities Human

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