| Gene Symbol |
NOTCH3
|
| Entrez Gene |
4854
|
| Alt Symbol |
CADASIL, CASIL, IMF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
notch 3
|
| Other Description |
Notch homolog 3|neurogenic locus notch homolog protein 3
|
| Swissprots |
Q9UEB3 Q9Y6L8 Q9UM47 Q9UPL3
|
| Accessions |
AAC04897 AAC14346 AAC15789 ACL52278 CAA55955 EAW84466 Q9UM47 AB209447 BAD92684 DQ156540 DQ156541 DQ156542 DQ156543 U97669 AAB91371 XM_005259924 XP_005259981 NM_000435 NP_000426
|
| Function |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Ubiquitously expressed in fetal and adult tissues.
|
| Top Pathways |
Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation
|