NOTCH3

Gene Symbol	NOTCH3
Entrez Gene	4854
Alt Symbol	CADASIL, CASIL, IMF2
Species	Human
Gene Type	protein-coding
Description	notch 3
Other Description	Notch homolog 3|neurogenic locus notch homolog protein 3
Swissprots	Q9UEB3 Q9Y6L8 Q9UM47 Q9UPL3
Accessions	AAC04897 AAC14346 AAC15789 ACL52278 CAA55955 EAW84466 Q9UM47 AB209447 BAD92684 DQ156540 DQ156541 DQ156542 DQ156543 U97669 AAB91371 XM_005259924 XP_005259981 NM_000435 NP_000426
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitously expressed in fetal and adult tissues.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human NOTCH3 peptide - ab26878 from Abcam Category Peptide

Human NOTCH3 protein fragment - ab114234 from Abcam Category Protein Source Wheat germ Species Human

NOTCH3 Antibody Blocking Peptide - LS-E8136 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOTCH3 Blocking Peptide - LS-E11202 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOTCH3 Antibody Blocking Peptide - LS-E25999 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Notch-3 Partial Recombinant Protein - H00004854-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Notch-3 Peptide - P1828 from Novus Biologicals Category Peptide Species Human

NOTCH3-Antibody-C-term-Blocking-Peptide - BP6220a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NOTCH3 blocking peptide - GTX89476-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant Human Notch-3 (aa 40-467) Fc Chimera, CF - 1559-NT-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (stably transfected)-derived

NOTCH3 Blocking Peptide - abx161182 from Abbexa Category Peptide Species Human, Mouse, Rat

NOTCH3 Blocking Peptide - abx161183 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

NOTCH3 Peptide - AC21-0827-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NOTCH3 - H00004854-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NOTCH3 - H00004854-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NOTCH3 Peptide - 45-978P from ProSci Category Peptide

Recombinant Human Notch Homolog 3 (Drosophila), Fc Chimera - NOTCH3-2543H from Creative Biomart Category Protein Source Sf21 cells.

Recombinant Human NOTCH3 - NOTCH3-29729TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Notch Homolog 3 (NOTCH3) - RPL147Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

NOTCH3 Blocking Peptide - CBP3681 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

NOTCH3 Blocking Peptide - CBP3682 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Notch Homolog 3 (NOTCH3) - RPL147Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Neurogenic locus notch homolog protein 3(NOTCH3) ,partial - CSB-YP892153HU CSB-EP892153HU CSB-BP892153HU CSB-MP892153HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF - 1559-NT from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 21 (stably transfected)-derived Human Notch-3 (Ala40 - Glu467) Accession # Q9UM47 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus Species Human

Notch Homolog 3 Protein (Recombinant) - abx168112 from Abbexa Category Protein Source Human Species Human

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