| Gene Symbol | NOTCH3 |
|---|---|
| Entrez Gene | 4854 |
| Alt Symbol | CADASIL, CASIL, IMF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | notch 3 |
| Other Description | Notch homolog 3|neurogenic locus notch homolog protein 3 |
| Swissprots | Q9UEB3 Q9Y6L8 Q9UM47 Q9UPL3 |
| Accessions | AAC04897 AAC14346 AAC15789 ACL52278 CAA55955 EAW84466 Q9UM47 AB209447 BAD92684 DQ156540 DQ156541 DQ156542 DQ156543 U97669 AAB91371 XM_005259924 XP_005259981 NM_000435 NP_000426 |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. |
| Top Pathways | Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation |