| Gene Symbol |
SEC13
|
| Entrez Gene |
6396
|
| Alt Symbol |
D3S1231E, SEC13L1, SEC13R, npp-20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SEC13 homolog (S. cerevisiae)
|
| Other Description |
SEC13-like 1 isoform|SEC13-like protein 1|SEC13-related protein|protein SEC13 homolog
|
| Swissprots |
Q9BUG7 Q9BRM6 P55735 B4DXJ1 Q5BJF0 A8MV37
|
| Accessions |
EAW64077 EAW64078 P55735 AA682381 AB209554 BAD92791 AF052155 AK095629 AK223019 BAD96739 AK294662 BAG57832 AK301999 BAG63403 BC002634 AAH02634 BC006167 AAH06167 BC091506 AAH91506 BE621430 CN344033 DB564012 EF036494 ABO65080 EU789555 ACH92821 L09260 XM_005265378 XP_005265435 XM_005265379 XP_005265436 XM_006713288 XP_006713351 XM_011533996 XP_011532298 XM_011533997 XP_011532299 NM_001136026 NP_001129498 NM_001136232 NP_001129704 NM_001278946 NP_001265875 NM_030673 NP_109598 NM_183352 NP_899195
|
| Function |
Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:8972206}.
|
| Subcellular Location |
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC.
|
| Top Pathways |
Protein processing in endoplasmic reticulum, RNA transport
|