Gene Symbol | SEC13 |
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Entrez Gene | 6396 |
Alt Symbol | D3S1231E, SEC13L1, SEC13R, npp-20 |
Species | Human |
Gene Type | protein-coding |
Description | SEC13 homolog (S. cerevisiae) |
Other Description | SEC13-like 1 isoform|SEC13-like protein 1|SEC13-related protein|protein SEC13 homolog |
Swissprots | Q9BUG7 Q9BRM6 P55735 B4DXJ1 Q5BJF0 A8MV37 |
Accessions | EAW64077 EAW64078 P55735 AA682381 AB209554 BAD92791 AF052155 AK095629 AK223019 BAD96739 AK294662 BAG57832 AK301999 BAG63403 BC002634 AAH02634 BC006167 AAH06167 BC091506 AAH91506 BE621430 CN344033 DB564012 EF036494 ABO65080 EU789555 ACH92821 L09260 XM_005265378 XP_005265435 XM_005265379 XP_005265436 XM_006713288 XP_006713351 XM_011533996 XP_011532298 XM_011533997 XP_011532299 NM_001136026 NP_001129498 NM_001136232 NP_001129704 NM_001278946 NP_001265875 NM_030673 NP_109598 NM_183352 NP_899195 |
Function | Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:8972206}. |
Subcellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC. |
Top Pathways | Protein processing in endoplasmic reticulum, RNA transport |
SEC13 CRISPR/Cas9 KO Plasmid (h) - sc-403302 from Santa Cruz Biotechnology
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SEC13 HDR Plasmid (h) - sc-403302-HDR from Santa Cruz Biotechnology
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SEC13 Double Nickase Plasmid (h) - sc-403302-NIC from Santa Cruz Biotechnology
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SEC13 Double Nickase Plasmid (h2) - sc-403302-NIC-2 from Santa Cruz Biotechnology
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SEC13 CRISPR Activation Plasmid (h) - sc-403302-ACT from Santa Cruz Biotechnology
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SEC13 CRISPR Activation Plasmid (h2) - sc-403302-ACT-2 from Santa Cruz Biotechnology
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SEC13 Lentiviral Activation Particles (h) - sc-403302-LAC from Santa Cruz Biotechnology
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SEC13 Lentiviral Activation Particles (h2) - sc-403302-LAC-2 from Santa Cruz Biotechnology
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SEC13 siRNA (h) - sc-78504 from Santa Cruz Biotechnology
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SEC13 shRNA Plasmid (h) - sc-78504-SH from Santa Cruz Biotechnology
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SEC13 shRNA (h) Lentiviral Particles - sc-78504-V from Santa Cruz Biotechnology
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SEC13 RNAi - H00006396-R01 from Novus Biologicals
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MISSION® esiRNA - EHU152131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19019 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19019 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02496 from Sigma-Aldrich
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SEC13 siRNA (Human) - CRH4318 from Cohesion Biosciences
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SEC13 - MBS8230177 from MyBioSource
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shRNA set against Human SEC13 (NM_183352.1) - SHH403636 from Creative biogene
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shRNA set against Human SEC13(NM_183352.1) - SHR211520 from Creative biogene
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SEC13 shRNA Plasmid (Human) - CHH4318 from Cohesion Biosciences
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SEC13 miRNA 3'UTR clone - MiUTR1H-09227 from Creative biogene
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SEC13 miRNA 3'UTR clone - MiUTR3H-03157 from Creative biogene
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