| Gene Symbol |
SMTNL1
|
| Entrez Gene |
219537
|
| Alt Symbol |
CHASM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
smoothelin-like 1
|
| Other Description |
calponin homology-associated smooth muscle protein|smoothelin-like protein 1
|
| Swissprots |
A8MU46
|
| Accessions |
A8MU46 BC172381 AAI72381 XM_005273819 XP_005273876 NM_001105565 NP_001099035
|
| Function |
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, myofibril {ECO:0000269|PubMed:18310078}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291}.
|