Gene Symbol | SMARCD3 |
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Entrez Gene | 6604 |
Alt Symbol | BAF60C, CRACD3, Rsc6p |
Species | Human |
Gene Type | protein-coding |
Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
Other Description | 60 kDa BRG-1/Brm-associated factor subunit C|BRG1-associated factor 60C|SWI/SNF complex 60 kDa subunit C|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3|Swp73-like protein|chromatin remodeling complex BAF60C subunit|mammalian chromatin remodeling complex BRG1-associated factor 60C |
Swissprots | Q6STE5 Q92926 Q2YD86 Q9BUH1 Q75MR8 D3DX10 Q75MJ2 |
Accessions | AAS00380 AAS02031 EAL24510 EAW54005 EAW54006 EAW54007 EAW54008 EAW54009 Q6STE5 AK127595 BAG54531 AK297876 BAH12684 AK309500 AK316173 BAH14544 AY450430 AAR88510 AY450431 AAR88511 BC002628 AAH02628 BC110350 AAI10351 BI598614 BX648385 U66619 AAC50697 XM_011516521 XP_011514823 XR_927517 XR_927518 XR_927519 NM_001003801 NP_001003801 NM_001003802 NP_001003802 NM_003078 NP_003069 |
Function | Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14701856}. |
Tissue Specificity | Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue. |
SMARCD3 (V-13) - sc-131787 from Santa Cruz Biotechnology
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SMARCD3 (RN-18) - sc-101163 from Santa Cruz Biotechnology
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SMARCD3 (F-20) - sc-102120 from Santa Cruz Biotechnology
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Anti-SMARCD3 antibody - ab171075 from Abcam
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Anti-SMARCD3 antibody - C-terminal - ab194671 from Abcam
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Anti-BAF60C / SMARCD3 Antibody - LS-C335218 from LifeSpan Bioscience
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Anti-BAF60C / SMARCD3 Antibody (C-Terminus) - LS-C145286 from LifeSpan Bioscience
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Anti-BAF60C / SMARCD3 Antibody (aa139-188) - LS-C30223 from LifeSpan Bioscience
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Anti-BAF60C / SMARCD3 Antibody - LS-C155333 from LifeSpan Bioscience
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Anti-BAF60C / SMARCD3 Antibody (clone 1G6) - LS-C198224 from LifeSpan Bioscience
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Anti-BAF60C / SMARCD3 Antibody (aa27-60) - LS-C344247 from LifeSpan Bioscience
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Anti-BAF60C / SMARCD3 Antibody (aa265-314) IHC-plus⢠- LS-B11644 from LifeSpan Bioscience
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SMARCD3 Antibody (1G6) - H00006604-M01 from Novus Biologicals
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SMARCD3 Antibody (5F12) - H00006604-M02 from Novus Biologicals
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SMARCD3 Antibody (5B6) - H00006604-M04 from Novus Biologicals
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SMARCD3 Antibody - NBP2-39013 from Novus Biologicals
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SMARCD3 Antibody - NBP2-15122 from Novus Biologicals
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SMARCD3 Antibody - NBP2-15121 from Novus Biologicals
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SMARCD3 Antibody (1G6) - H00006604-M01A from Novus Biologicals
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SMARCD3 Antibody (5G4) - H00006604-M03A from Novus Biologicals
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SMARCD3 Antibody - H00006604-A01 from Novus Biologicals
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SMARCD3 Polyclonal Antibody - bs-9479R from Bioss
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Monoclonal Anti-SMARCD3 antibody produced in mouse - SAB1409690 from Sigma-Aldrich
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Monoclonal Anti-SMARCD3 antibody produced in mouse - WH0006604M1 from Sigma-Aldrich
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Anti-SMARCD3 antibody produced in rabbit - SAB2104363 from Sigma-Aldrich
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