SMARCD3
| Gene Symbol | SMARCD3 |
|---|---|
| Entrez Gene | 6604 |
| Alt Symbol | BAF60C, CRACD3, Rsc6p |
| Species | Human |
| Gene Type | protein-coding |
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| Other Description | 60 kDa BRG-1/Brm-associated factor subunit C|BRG1-associated factor 60C|SWI/SNF complex 60 kDa subunit C|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3|Swp73-like protein|chromatin remodeling complex BAF60C subunit|mammalian chromatin remodeling complex BRG1-associated factor 60C |
| Swissprots | Q6STE5 Q92926 Q2YD86 Q9BUH1 Q75MR8 D3DX10 Q75MJ2 |
| Accessions | AAS00380 AAS02031 EAL24510 EAW54005 EAW54006 EAW54007 EAW54008 EAW54009 Q6STE5 AK127595 BAG54531 AK297876 BAH12684 AK309500 AK316173 BAH14544 AY450430 AAR88510 AY450431 AAR88511 BC002628 AAH02628 BC110350 AAI10351 BI598614 BX648385 U66619 AAC50697 XM_011516521 XP_011514823 XR_927517 XR_927518 XR_927519 NM_001003801 NP_001003801 NM_001003802 NP_001003802 NM_003078 NP_003069 |
| Function | Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:14701856}. |
| Tissue Specificity | Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue. |
SMARCD3 CRISPR/Cas9 KO Plasmid (h) - sc-402705 from Santa Cruz Biotechnology
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SMARCD3 HDR Plasmid (h) - sc-402705-HDR from Santa Cruz Biotechnology
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SMARCD3 Double Nickase Plasmid (h) - sc-402705-NIC from Santa Cruz Biotechnology
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SMARCD3 Double Nickase Plasmid (h2) - sc-402705-NIC-2 from Santa Cruz Biotechnology
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SMARCD3 CRISPR Activation Plasmid (h) - sc-402705-ACT from Santa Cruz Biotechnology
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SMARCD3 CRISPR Activation Plasmid (h2) - sc-402705-ACT-2 from Santa Cruz Biotechnology
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SMARCD3 Lentiviral Activation Particles (h) - sc-402705-LAC from Santa Cruz Biotechnology
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SMARCD3 Lentiviral Activation Particles (h2) - sc-402705-LAC-2 from Santa Cruz Biotechnology
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SMARCD3 siRNA (h) - sc-89355 from Santa Cruz Biotechnology
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SMARCD3 shRNA Plasmid (h) - sc-89355-SH from Santa Cruz Biotechnology
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SMARCD3 shRNA (h) Lentiviral Particles - sc-89355-V from Santa Cruz Biotechnology
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SMARCD3 RNAi - H00006604-R03 from Novus Biologicals
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SMARCD3 RNAi - H00006604-R02 from Novus Biologicals
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MISSION® esiRNA - EHU078651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19771 from Sigma-Aldrich
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SMARCD3 siRNA (Human) - CRH4487 from Cohesion Biosciences
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SMARCD3 RNAi - H00006604-R01 from Novus Biologicals
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SMARCD3 - MBS8227845 from MyBioSource
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shRNA set against Human SMARCD3 (NM_003078.3) - SHH413204 from Creative biogene
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shRNA set against Human SMARCD3(NM_001003801.1) - SHL016070 from Creative biogene
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shRNA set against Human SMARCD3(NM_001003802.1) - SHL016128 from Creative biogene
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shRNA set against Human SMARCD3(NM_001003801.1) - SHL016182 from Creative biogene
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Human SMARCD3 siRNA - orb264989 from Biorbyt
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SMARCD3 shRNA Plasmid (Human) - CHH4487 from Cohesion Biosciences
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